3SPK

Tipranavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant

Summary for 3SPK

• Entry DOI: 10.2210/pdb3spk/pdb
• Related: 1RPI 1TW7 3OQ7 3OQA 3OQD 3SO9
• Descriptor: HIV-1 protease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE (3 entities in total)
• Functional Keywords: tipranavir, multi-drug resistant hiv-1 protease, hydorlase-hydorlase inhibitor complex, hydorlase/hydorlase inhibitor
• Biological source: human immunodeficiency virus type 1 (HIV)
• Total number of polymer chains: 2
• Total formula weight: 22746.70

Authors

Wang, Y.,Liu, Z.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. (deposition date: 2011-07-01, release date: 2011-10-12, Last modification date: 2024-02-28)

• Primary citation: Wang, Y.,Liu, Z.,Brunzelle, J.S.,Kovari, I.A.,Dewdney, T.G.,Reiter, S.J.,Kovari, L.C.; The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.; Biochem.Biophys.Res.Commun., 412:737-742, 2011; PubMed: 21871444; DOI: 10.1016/j.bbrc.2011.08.045

Experimental method

X-RAY DIFFRACTION (1.24 Å)