4YOB

Crystal Structure of Apo HIV-1 Protease MDR769 L33F

Summary for 4YOB

• Entry DOI: 10.2210/pdb4yob/pdb
• Related: 4YOA
• Descriptor: HIV-1 Protease (2 entities in total)
• Functional Keywords: hiv-1 protease, mdr769 33f, molecular anchor, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 10804.70

Authors

Kuiper, B.D.,Keusch, B.,Dewdney, T.G.,Chordia, P.,Ross, K.,Brunzelle, J.S.,Kovari, I.A.,MacArthur, R.,Salimnia, H.,Kovari, L.C. (deposition date: 2015-03-11, release date: 2015-07-08, Last modification date: 2024-02-28)

• Primary citation: Kuiper, B.D.,Keusch, B.J.,Dewdney, T.G.,Chordia, P.,Ross, K.,Brunzelle, J.S.,Kovari, I.A.,MacArthur, R.,Salimnia, H.,Kovari, L.C.; The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.; Biochem Biophys Rep, 2:160-165, 2015; PubMed: 29124158; DOI: 10.1016/j.bbrep.2015.06.003

Experimental method

X-RAY DIFFRACTION (1.504 Å)