4YOA

Crsystal structure HIV-1 Protease MDR769 L33F Complexed with darunavir

Summary for 4YOA

• Entry DOI: 10.2210/pdb4yoa/pdb
• Related: 4YOB
• Descriptor: HIV-1 Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• Functional Keywords: hiv-1 protease, complex, darunavir, hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 11352.37

Authors

Kuiper, B.D.,Keusch, B.,Dewdney, T.G.,Chordia, P.,Brunzelle, J.S.,Ross, K.,Kovari, I.A.,MacArthur, R.,Salimnia, H.,Kovari, L.C. (deposition date: 2015-03-11, release date: 2015-07-08, Last modification date: 2023-09-27)

• Primary citation: Kuiper, B.D.,Keusch, B.J.,Dewdney, T.G.,Chordia, P.,Ross, K.,Brunzelle, J.S.,Kovari, I.A.,MacArthur, R.,Salimnia, H.,Kovari, L.C.; The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.; Biochem Biophys Rep, 2:160-165, 2015; PubMed: 29124158; DOI: 10.1016/j.bbrep.2015.06.003

Experimental method

X-RAY DIFFRACTION (1.697 Å)