4YOA
Crsystal structure HIV-1 Protease MDR769 L33F Complexed with darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | HIV-1 Protease | polymer | 99 | 10804.7 | 1 | UniProt (Q5RTL1) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
| 2 | A | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 3 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q5RTL1)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
| Phe 33 | Leu 33 | engineered mutation |
| Val 36 | Met 36 | engineered mutation |
| Thr 82 | Ala 82 | engineered mutation |
| Val 84 | Ile 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10804.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 11352.4 |
