4YOA
Crsystal structure HIV-1 Protease MDR769 L33F Complexed with darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIV-1 Protease | polymer | 99 | 10804.7 | 1 | UniProt (Q5RTL1) | Human immunodeficiency virus 1 | |
| 2 | B (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) PubChem (44400512) PubChem (44578485) PubChem (23545473) PubChem (52949690) PubChem (213039) PubChem (58330571) PubChem (60170302) PubChem (70329566) PubChem (66725685) PubChem (89334570) PubChem (3001874) PubChem (89394603) PubChem (102206609) PubChem (6320435) PubChem (125136514) PubChem (6320436) PubChem (6320437) PubChem (101897907) PubChem (102206607) PubChem (102206608) PubChem (118243427) PubChem (118243428) PubChem (118243429) PubChem (125136515) PubChem (129010372) PubChem (131632443) PubChem (131667685) PubChem (134694394) PubChem (137704505) PubChem (137704865) PubChem (138631483) PubChem (138631484) PubChem (138631622) PubChem (144227995) PubChem (145507139) PubChem (147231834) PubChem (156183881) PubChem (156183911) PubChem (171370671) | |||
| 3 | C (A) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q5RTL1)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
| Phe 33 | Leu 33 | engineered mutation |
| Val 36 | Met 36 | engineered mutation |
| Thr 82 | Ala 82 | engineered mutation |
| Val 84 | Ile 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10804.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 11352.4 |
