4GYE

MDR 769 HIV-1 Protease in Complex with Reduced P1F

Summary for 4GYE

Entry DOI	10.2210/pdb4gye/pdb
Related	4GZF
Related PRD ID	PRD_000778
Descriptor	Protease, P1F peptide (3 entities in total)
Functional Keywords	multi-drug resistance, protease inhibitor, drug resistance, substrate peptide, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	3
Total formula weight	22409.42
Authors	Dewdney, T.G.,Wang, Y.,Brunzelle, J.,Reiter, S.J.,Kovari, I.A.,Kovari, L.C. (deposition date: 2012-09-05, release date: 2013-10-30, Last modification date: 2023-11-15)
Primary citation	Dewdney, T.G.,Wang, Y.,Liu, Z.,Sharma, S.K.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Woster, P.M.,Kovari, L.C. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg.Med.Chem., 21:7430-7434, 2013 Cited by PubMed: 24128815 DOI: 10.1016/j.bmc.2013.09.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation