6MPB
| Cryo-EM structure of the human neutral amino acid transporter ASCT2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMINE, Neutral amino acid transporter B(0) | Authors: | Yu, X, Han, S. | Deposit date: | 2018-10-05 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation. Elife, 8, 2019
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6NZU
| Structure of the human frataxin-bound iron-sulfur cluster assembly complex | Descriptor: | Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... | Authors: | Fox, N.G, Yu, X, Xidong, F, Alain, M, Joseph, N, Claire, S.D, Christine, B, Han, S, Yue, W.W. | Deposit date: | 2019-02-14 | Release date: | 2019-05-22 | Last modified: | 2019-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. Nat Commun, 10, 2019
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7XK8
| Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, W, Wenru, Z, Mu, W, Minmin, L, Shutian, C, Tingting, T, Gisela, S, Holger, W, Albert, B, Cuiying, Y, Xiaojing, C, Han, S, Wu, B, Zhao, Q. | Deposit date: | 2022-04-19 | Release date: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ligand recognition and activation of neuromedin U receptor 2. Nat Commun, 13, 2022
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7UJN
| Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog | Descriptor: | 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Authors: | Huynh, K.W, Ammirati, M, Han, S. | Deposit date: | 2022-03-31 | Release date: | 2022-07-20 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Nucleic Acids Res., 50, 2022
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7XNA
| Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806 | Descriptor: | CYN 154806, Somatostatin receptor type 2,Endo-1,4-beta-xylanase | Authors: | Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q. | Deposit date: | 2022-04-28 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res., 32, 2022
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7XN9
| Crystal structure of SSTR2 and L-054,522 complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Somatostatin receptor type 2,Endo-1,4-beta-xylanase, tert-butyl (2S)-6-azanyl-2-[[(2R,3S)-3-(1H-indol-3-yl)-2-[[4-(2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]carbonylamino]butanoyl]amino]hexanoate | Authors: | Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q. | Deposit date: | 2022-04-28 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res., 32, 2022
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7X9B
| Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Tang, T, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-03-15 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7X9C
| Cryo-EM structure of neuropeptide Y Y4 receptor in complex with PP and Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Tang, T, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-03-15 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7X9A
| Cryo-EM structure of neuropeptide Y Y1 receptor in complex with NPY and Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Tang, T, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-03-15 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7DDZ
| The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028 | Descriptor: | FLAVIN MONONUCLEOTIDE, Human Neuropeptide Y Y2 Receptor fusion protein, ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide | Authors: | Tang, T, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2020-10-30 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for ligand recognition of the neuropeptide Y Y 2 receptor. Nat Commun, 12, 2021
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7F1R
| Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi | Descriptor: | C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | Deposit date: | 2021-06-09 | Release date: | 2021-07-14 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1S
| Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi | Descriptor: | C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | Deposit date: | 2021-06-09 | Release date: | 2021-07-14 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1T
| Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a | Descriptor: | C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | Deposit date: | 2021-06-09 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1Q
| Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi | Descriptor: | C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | Deposit date: | 2021-06-09 | Release date: | 2021-07-14 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7KDP
| HCMV prefusion gB in complex with fusion inhibitor WAY-174865 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ... | Authors: | Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X. | Deposit date: | 2020-10-09 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7, 2021
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7KDD
| HCMV postfusion gB in complex with SM5-1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ... | Authors: | Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X. | Deposit date: | 2020-10-08 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7, 2021
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7WVW
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | Descriptor: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVY
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | Descriptor: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVX
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVU
| Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 | Descriptor: | FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVV
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | Descriptor: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7XBW
| Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1 | Descriptor: | CHOLESTEROL, CX3C chemokine receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2022-03-22 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7XBX
| Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2022-03-22 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7XXH
| Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 | Descriptor: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-05-30 | Release date: | 2023-06-07 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. Protein Cell, 14, 2023
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7XXI
| Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi | Descriptor: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-05-30 | Release date: | 2023-06-07 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. Protein Cell, 14, 2023
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