7KDP

HCMV prefusion gB in complex with fusion inhibitor WAY-174865

Summary for 7KDP

Entry DOI	10.2210/pdb7kdp/pdb
EMDB information	22828
Descriptor	Envelope glycoprotein B, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{4-[({(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}carbamothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, ... (4 entities in total)
Functional Keywords	fusogen, prefusion, hcmv, gb, antibody, viral protein, fusion inhibitor, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human cytomegalovirus (strain Towne) (HHV-5)
Total number of polymer chains	3
Total formula weight	314434.88
Authors	Liu, Y.,Heim, P.K.,Che, Y.,Chi, X.,Qiu, X.,Han, S.,Dormitzer, P.R.,Yang, X. (deposition date: 2020-10-09, release date: 2021-03-17)
Primary citation	Liu, Y.,Heim, K.P.,Che, Y.,Chi, X.,Qiu, X.,Han, S.,Dormitzer, P.R.,Yang, X. Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7:-, 2021 Cited by PubMed: 33674318 DOI: 10.1126/sciadv.abf3178 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation