3BYP
 
 | | Mode of Action of a Putative Zinc Transporter CzrB | | Descriptor: | CzrB protein, SULFATE ION | | Authors: | Cherezov, V, Srinivasan, V, Szebenyi, D.M.E, Caffrey, M. | | Deposit date: | 2008-01-16 | | Release date: | 2008-09-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus
Structure, 16, 2008
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3BYR
 | | Mode of Action of a Putative Zinc Transporter CzrB (Zn form) | | Descriptor: | CzrB protein, ZINC ION | | Authors: | Cherezov, V, Srinivasan, V, Szebenyi, D.M.E, Caffrey, M. | | Deposit date: | 2008-01-16 | | Release date: | 2008-09-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus
Structure, 16, 2008
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2RH1
 | | High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. | | Descriptor: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ... | | Authors: | Cherezov, V, Rosenbaum, D.M, Hanson, M.A, Rasmussen, S.G.F, Thian, F.S, Kobilka, T.S, Choi, H.J, Kuhn, P, Weis, W.I, Kobilka, B.K, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR) | | Deposit date: | 2007-10-05 | | Release date: | 2007-10-30 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
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2VDF
 | | Structure of the OpcA adhesion from Neisseria meningitidis determined by crystallization from the cubic mesophase | | Descriptor: | N-OCTANE, OUTER MEMBRANE PROTEIN, SULFATE ION | | Authors: | Cherezov, V, Liu, W, Derrick, J.P, Luan, B, Aksimentiev, A, Katritch, V, Caffrey, M. | | Deposit date: | 2007-10-05 | | Release date: | 2007-10-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin.
Proteins, 71, 2008
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2FKW
 | | Structure of LH2 from Rps. acidophila crystallized in lipidic mesophases | | Descriptor: | BACTERIOCHLOROPHYLL A, LAURYL DIMETHYLAMINE-N-OXIDE, Light-harvesting protein B-800/850, ... | | Authors: | Papiz, M.Z, Cherezov, V, Clogston, J, Caffrey, M. | | Deposit date: | 2006-01-05 | | Release date: | 2006-03-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases
J.Mol.Biol., 357, 2006
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2GUF
 | | In meso crystal structure of the cobalamin transporter, BtuB | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, FORMIC ACID, Vitamin B12 transporter btuB, ... | | Authors: | Caffrey, M, Cherezov, V, Yamashita, E, Cramer, W.A. | | Deposit date: | 2006-04-29 | | Release date: | 2006-12-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 A Resolution.
J.Mol.Biol., 364, 2006
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7JNI
 | | Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, HEXANE-1,6-DIOL, ... | | Authors: | Cherezov, V, Shaye, H, Han, G.W. | | Deposit date: | 2020-08-04 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma.
Proc.Natl.Acad.Sci.USA, 119, 2022
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3S8F
 | | 1.8 A structure of ba3 cytochrome c oxidase from Thermus thermophilus in lipid environment | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | | Authors: | Tiefenbrunn, T, Liu, W, Chen, Y, Katritch, V, Stout, C.D, Fee, J.A, Cherezov, V. | | Deposit date: | 2011-05-27 | | Release date: | 2011-08-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.
Plos One, 6, 2011
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7YXA
 | | XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... | | Authors: | Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | | Deposit date: | 2022-02-15 | | Release date: | 2022-08-10 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors.
Nat Commun, 13, 2022
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6PNY
 | | X-ray Structure of Flpp3 | | Descriptor: | Flpp3 | | Authors: | Zook, J.D, Shekhar, M, Hansen, D.T, Conrad, C, Grant, T.D, Gupta, C, White, T, Barty, A, Basu, S, Zhao, Y, Zatsepin, N.A, Ishchenko, A, Batyuk, A, Gati, C, Li, C, Galli, L, Coe, J, Hunter, M, Liang, M, Weierstall, U, Nelson, G, James, D, Stauch, B, Craciunescu, F, Thifault, D, Liu, W, Cherezov, V, Singharoy, A, Fromme, P. | | Deposit date: | 2019-07-03 | | Release date: | 2020-02-26 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.
Structure, 28, 2020
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6UO9
 | | Human metabotropic GABA(B) receptor bound to agonist SKF97541 in its intermediate state 2 | | Descriptor: | (R)-(3-aminopropyl)methylphosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | | Deposit date: | 2019-10-14 | | Release date: | 2020-06-10 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
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6UOA
 | | Human metabotropic GABA(B) receptor in its intermediate state 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ... | | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | | Deposit date: | 2019-10-14 | | Release date: | 2020-06-10 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
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8DU3
 | | Crystal structure of A2AAR-StaR2-bRIL in complex with compound 21a | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (4M)-6-bromo-4-(furan-2-yl)quinazolin-2-amine, Adenosine receptor A2a, ... | | Authors: | Shiriaeva, A, Stauch, B, Han, G.W, Cherezov, V. | | Deposit date: | 2022-07-26 | | Release date: | 2022-08-10 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | High ligand efficiency quinazoline compounds as novel A 2A adenosine receptor antagonists.
Eur.J.Med.Chem., 241, 2022
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6B73
 | | Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor | | Descriptor: | CHOLESTEROL, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, Nanobody, ... | | Authors: | Che, T, Majumdar, S, Zaidi, S.A, Kormos, C, McCorvy, J.D, Wang, S, Mosier, P.D, Uprety, R, Vardy, E, Krumm, B.E, Han, G.W, Lee, M.Y, Pardon, E, Steyaert, J, Huang, X.P, Strachan, R.T, Tribo, A.R, Pasternak, G.W, Carroll, I.F, Stevens, R.C, Cherezov, V, Katritch, V, Wacker, D, Roth, B.L. | | Deposit date: | 2017-10-03 | | Release date: | 2018-01-17 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
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8TYW
 | | cryo-EM structure of GPR6-Gs-Nb35 complex | | Descriptor: | G-protein coupled receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Barekatain, M, Johansson, L.C, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, J, Hua, T, Katritch, V, Cherezov, V. | | Deposit date: | 2023-08-26 | | Release date: | 2024-12-04 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
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7SK2
 | | Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation | | Descriptor: | Sodium- and chloride-dependent GABA transporter 1, Tiagabine | | Authors: | Gati, C, Motiwala, Z, Aduri, N.G, Shaye, H, Han, G.W, Cherezov, V. | | Deposit date: | 2021-10-19 | | Release date: | 2022-06-08 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.82 Å) | | Cite: | Structural basis of GABA reuptake inhibition.
Nature, 606, 2022
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6MH8
 | | High-viscosity injector-based Pink Beam Serial Crystallography of Micro-crystals at a Synchrotron Radiation Source | | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct | | Authors: | Martin-Garcia, J.M, Zhu, L, Mendez, D, Lee, M, Chun, E, Li, C, Hu, H, Subramanian, G, Kissick, D, Ogata, C, Henning, R, Ishchenko, A, Dobson, Z, Zhan, S, Weierstall, U, Spence, J.C.H, Fromme, P, Zatsepin, N.A, Fischetti, R.F, Cherezov, V, Liu, W. | | Deposit date: | 2018-09-17 | | Release date: | 2019-04-24 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Iucrj, 6, 2019
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9IYA
 | | Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex | | Descriptor: | 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide, G-protein coupled receptor 55,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ... | | Authors: | Hua, T, Liu, Z.J, Cherezov, V, Chang, H, Li, X.T, Shen, L. | | Deposit date: | 2024-07-30 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structure basis of ligand recognition and activation of GPR55.
Cell Res., 35, 2025
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9IY8
 | | Cryo-EM structure of apo-GPR55-G13 complex | | Descriptor: | G-protein coupled receptor 55, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Hua, T, Liu, Z.J, Cherezov, V, Chang, H, Li, X.T, Shen, L. | | Deposit date: | 2024-07-30 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structure basis of ligand recognition and activation of GPR55.
Cell Res., 35, 2025
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8CU6
 | | Crystal structure of A2AAR-StaR2-S277-bRIL in complex with a novel A2a antagonist, LJ-4517 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol, Adenosine receptor A2a,Soluble cytochrome b562, ... | | Authors: | Shiriaeva, A, Park, D.-J, Kim, G, Lee, Y, Hou, X, Jarhad, D.B, Kim, G, Yu, J, Hyun, Y.E, Kim, W, Gao, Z.-G, Jacobson, K.A, Han, G.W, Stevens, R.C, Jeong, L.S, Choi, S, Cherezov, V. | | Deposit date: | 2022-05-16 | | Release date: | 2022-08-31 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor.
J.Med.Chem., 65, 2022
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8CU7
 | | Crystal structure of A2AAR-StaR2-bRIL in complex with a novel A2a antagonist, LJ-4517 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol, Adenosine receptor A2a,Soluble cytochrome b562, ... | | Authors: | Shiriaeva, A, Park, D.-J, Kim, G, Lee, Y, Hou, X, Jarhad, D.B, Kim, G, Yu, J, Hyun, Y.E, Kim, W, Gao, Z.-G, Jacobson, K.A, Han, G.W, Stevens, R.C, Jeong, L.S, Choi, S, Cherezov, V. | | Deposit date: | 2022-05-16 | | Release date: | 2022-08-31 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor.
J.Med.Chem., 65, 2022
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8TF5
 | | Crystal structure of orphan G protein-coupled receptor 6, pseudoapo form | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, CHOLESTEROL, ... | | Authors: | Barekatain, M, Johansson, L, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, Z, Hua, T, Katritch, V, Cherezov, V. | | Deposit date: | 2023-07-07 | | Release date: | 2024-12-04 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
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8T1W
 | | Crystal structure of orphan G protein-coupled receptor 6 with bound CVN424 | | Descriptor: | 1-{2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl}ethan-1-one, G-protein coupled receptor 6, Soluble cytochrome b562 chimera | | Authors: | Barekatain, M, Johansson, L, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, Z, Hua, T, Katritch, V, Cherezov, V. | | Deposit date: | 2023-06-04 | | Release date: | 2024-12-04 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
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8T1V
 | | Crystal structure of orphan G protein-coupled receptor 6 with bound inverse agonist 3h | | Descriptor: | 3-{4-[(2,4-difluorophenyl)methyl]piperazin-1-yl}-7-methyl-N-(propan-2-yl)pyrido[3,4-b]pyrazin-2-amine, G-protein coupled receptor 6, Soluble cytochrome b562 chimera, ... | | Authors: | Barekatain, M, Johansson, L, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, Z, Hua, T, Katritch, V, Cherezov, V. | | Deposit date: | 2023-06-04 | | Release date: | 2024-12-04 | | Last modified: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
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6VJM
 | | Human metabotropic GABA(B) receptor in its apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | | Deposit date: | 2020-01-16 | | Release date: | 2020-06-10 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
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