6B73
Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Summary for 6B73
Entry DOI | 10.2210/pdb6b73/pdb |
Descriptor | Soluble cytochrome b562, kappa-type opioid receptor, Nanobody, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, ... (5 entities in total) |
Functional Keywords | gpcr, opioid receptor, addiction, active state, nanobody, structure-function, morphinan, lcp, membrane protein, membrane protein-agonist complex, membrane protein/agonist |
Biological source | Escherichia coli More |
Total number of polymer chains | 4 |
Total formula weight | 126051.35 |
Authors | Che, T.,Majumdar, S.,Zaidi, S.A.,Kormos, C.,McCorvy, J.D.,Wang, S.,Mosier, P.D.,Uprety, R.,Vardy, E.,Krumm, B.E.,Han, G.W.,Lee, M.Y.,Pardon, E.,Steyaert, J.,Huang, X.P.,Strachan, R.T.,Tribo, A.R.,Pasternak, G.W.,Carroll, I.F.,Stevens, R.C.,Cherezov, V.,Katritch, V.,Wacker, D.,Roth, B.L. (deposition date: 2017-10-03, release date: 2018-01-17, Last modification date: 2023-10-04) |
Primary citation | Che, T.,Majumdar, S.,Zaidi, S.A.,Ondachi, P.,McCorvy, J.D.,Wang, S.,Mosier, P.D.,Uprety, R.,Vardy, E.,Krumm, B.E.,Han, G.W.,Lee, M.Y.,Pardon, E.,Steyaert, J.,Huang, X.P.,Strachan, R.T.,Tribo, A.R.,Pasternak, G.W.,Carroll, F.I.,Stevens, R.C.,Cherezov, V.,Katritch, V.,Wacker, D.,Roth, B.L. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell, 172:55-67.e15, 2018 Cited by PubMed: 29307491DOI: 10.1016/j.cell.2017.12.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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