6B73

Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor

Summary for 6B73

Entry DOI	10.2210/pdb6b73/pdb
Descriptor	Soluble cytochrome b562, kappa-type opioid receptor, Nanobody, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, ... (5 entities in total)
Functional Keywords	gpcr, opioid receptor, addiction, active state, nanobody, structure-function, morphinan, lcp, membrane protein, membrane protein-agonist complex, membrane protein/agonist
Biological source	Escherichia coli More
Total number of polymer chains	4
Total formula weight	126051.35
Authors	Che, T.,Majumdar, S.,Zaidi, S.A.,Kormos, C.,McCorvy, J.D.,Wang, S.,Mosier, P.D.,Uprety, R.,Vardy, E.,Krumm, B.E.,Han, G.W.,Lee, M.Y.,Pardon, E.,Steyaert, J.,Huang, X.P.,Strachan, R.T.,Tribo, A.R.,Pasternak, G.W.,Carroll, I.F.,Stevens, R.C.,Cherezov, V.,Katritch, V.,Wacker, D.,Roth, B.L. (deposition date: 2017-10-03, release date: 2018-01-17, Last modification date: 2023-10-04)
Primary citation	Che, T.,Majumdar, S.,Zaidi, S.A.,Ondachi, P.,McCorvy, J.D.,Wang, S.,Mosier, P.D.,Uprety, R.,Vardy, E.,Krumm, B.E.,Han, G.W.,Lee, M.Y.,Pardon, E.,Steyaert, J.,Huang, X.P.,Strachan, R.T.,Tribo, A.R.,Pasternak, G.W.,Carroll, F.I.,Stevens, R.C.,Cherezov, V.,Katritch, V.,Wacker, D.,Roth, B.L. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell, 172:55-67.e15, 2018 Cited by PubMed: 29307491 DOI: 10.1016/j.cell.2017.12.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation