6B73
Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0038048 | molecular_function | dynorphin receptor activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0038048 | molecular_function | dynorphin receptor activity |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue CVV A 2001 |
| Chain | Residue |
| A | GLN115 |
| A | TYR312 |
| A | ILE316 |
| A | GLY319 |
| A | TYR320 |
| A | VAL134 |
| A | LEU135 |
| A | ASP138 |
| A | TYR139 |
| A | MET142 |
| A | CYS210 |
| A | TRP287 |
| A | ILE294 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CLR A 2002 |
| Chain | Residue |
| A | VAL284 |
| A | VAL285 |
| A | PHE293 |
| A | THR302 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 2003 |
| Chain | Residue |
| A | ALA57 |
| A | ILE61 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue CVV B 2001 |
| Chain | Residue |
| B | GLN115 |
| B | VAL134 |
| B | LEU135 |
| B | ASP138 |
| B | TYR139 |
| B | MET142 |
| B | CYS210 |
| B | ILE294 |
| B | TYR312 |
| B | ILE316 |
| B | GLY319 |
| B | TYR320 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CLR B 2002 |
| Chain | Residue |
| B | VAL284 |
| B | VAL285 |
| B | PHE293 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMSVDRYIaV |
| Chain | Residue | Details |
| A | THR144-VAL160 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP-48 | |
| A | ILE47 | |
| B | TRP-48 | |
| B | ILE47 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| A | ILE58-ILE85 | |
| B | ILE58-ILE85 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | ARG86-ASN95 | |
| A | ASP155-LEU173 | |
| A | LEU248-ARG274 | |
| B | ARG86-ASN95 | |
| B | ASP155-LEU173 | |
| B | LEU248-ARG274 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | ILE96-TYR119 | |
| B | ILE96-TYR119 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 102 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | LEU120-LYS132 | |
| A | GLY197-TRP222 | |
| A | GLU297-SER311 | |
| B | LEU120-LYS132 | |
| B | GLY197-TRP222 | |
| B | GLU297-SER311 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | ILE133-VAL154 | |
| B | ILE133-VAL154 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | LYS174-LEU196 | |
| B | LYS174-LEU196 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | ASP223-THR247 | |
| B | ASP223-THR247 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | LEU275-VAL296 | |
| B | LEU275-VAL296 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | TYR312-LEU333 | |
| B | TYR312-LEU333 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS345 | |
| B | CYS345 |
