7SK2
Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation
Summary for 7SK2
Entry DOI | 10.2210/pdb7sk2/pdb |
EMDB information | 25170 |
Descriptor | Sodium- and chloride-dependent GABA transporter 1, Tiagabine (2 entities in total) |
Functional Keywords | neurotransmitter transporter, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 65262.34 |
Authors | Gati, C.,Motiwala, Z.,Aduri, N.G.,Shaye, H.,Han, G.W.,Cherezov, V. (deposition date: 2021-10-19, release date: 2022-06-08, Last modification date: 2022-07-06) |
Primary citation | Motiwala, Z.,Aduri, N.G.,Shaye, H.,Han, G.W.,Lam, J.H.,Katritch, V.,Cherezov, V.,Gati, C. Structural basis of GABA reuptake inhibition. Nature, 606:820-826, 2022 Cited by PubMed: 35676483DOI: 10.1038/s41586-022-04814-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.82 Å) |
Structure validation
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