4WHF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4whf by Molmil](/molmil-images/mine/4whf) | Crystal Structure of TR3 LBD in complex with 1-(3,4,5-trihydroxyphenyl)decan-1-one | Descriptor: | 1-(3,4,5-trihydroxyphenyl)decan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | Authors: | Li, F.W, Cai, Q.X, Li, A.Z, Tian, X.Y, Wang, W.J, Wang, Y, Hou, P.P, Wu, Q, Lin, T.W. | Deposit date: | 2014-09-22 | Release date: | 2015-09-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity Chem.Biol., 22, 2015
|
|
5H1J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h1j by Molmil](/molmil-images/mine/5h1j) | Crystal structure of WD40 repeat domains of Gemin5 | Descriptor: | Gem-associated protein 5 | Authors: | Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M. | Deposit date: | 2016-10-10 | Release date: | 2016-11-23 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5 Genes Dev., 30, 2016
|
|
7CAC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cac by Molmil](/molmil-images/mine/7cac) | SARS-CoV-2 S trimer with one RBD in the open state and complexed with one H014 Fab. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H014 Fab, ... | Authors: | Zhe, L, Cao, L, Deng, Y, Sun, Y, Wang, N, Xie, L, Wang, Y, Rao, Z, Qin, C, Wang, X. | Deposit date: | 2020-06-08 | Release date: | 2021-02-24 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science, 369, 2020
|
|
8JFQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jfq by Molmil](/molmil-images/mine/8jfq) | Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-back Loop | Descriptor: | 26mer-DNA | Authors: | Liu, Y, Li, J, Zhang, Y, Wang, Y, Chen, J, Bian, Y, Xia, Y, Yang, M.H, Zheng, K, Wang, K.B, Kong, L.Y. | Deposit date: | 2023-05-18 | Release date: | 2023-08-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop. J.Am.Chem.Soc., 145, 2023
|
|
8SNN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8snn by Molmil](/molmil-images/mine/8snn) | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1 | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | Deposit date: | 2023-04-27 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.32 Å) | Cite: | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1 To Be Published
|
|
8SNM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8snm by Molmil](/molmil-images/mine/8snm) | Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Disintegrin and metalloproteinase domain-containing protein 17 propeptide, ... | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | Deposit date: | 2023-04-27 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain To Be Published
|
|
7TRD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7trd by Molmil](/molmil-images/mine/7trd) | Human telomerase catalytic core structure at 3.3 Angstrom | Descriptor: | Telomerase RNA, partial sequence, Telomerase reverse transcriptase, ... | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-01-28 | Release date: | 2022-04-20 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
|
|
7TRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7trf by Molmil](/molmil-images/mine/7trf) | Human telomerase catalytic core RNP with H2A/H2B | Descriptor: | Histone H2A, Histone H2B type 1-C/E/F/G/I, Telomerase RNA, ... | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-01-28 | Release date: | 2022-04-20 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
|
|
7TRE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tre by Molmil](/molmil-images/mine/7tre) | Human telomerase catalytic core with shelterin protein TPP1 | Descriptor: | Adrenocortical dysplasia protein homolog, Telomerase RNA, partial sequence, ... | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-01-28 | Release date: | 2022-04-20 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
|
|
7TRC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7trc by Molmil](/molmil-images/mine/7trc) | Human telomerase H/ACA RNP at 3.3 Angstrom | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-01-28 | Release date: | 2022-04-20 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
|
|
4N47
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n47 by Molmil](/molmil-images/mine/4n47) | Structure of Thermus thermophilus Argonaute bound to guide DNA and 12-mer target DNA | Descriptor: | 5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ... | Authors: | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | Deposit date: | 2013-10-08 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.823 Å) | Cite: | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4NCB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ncb by Molmil](/molmil-images/mine/4ncb) | Structure of Thermus thermophilus Argonaute bound to guide DNA and 19-mer target DNA with Mg2+ | Descriptor: | 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3', 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ... | Authors: | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | Deposit date: | 2013-10-24 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.189 Å) | Cite: | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
7UY7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uy7 by Molmil](/molmil-images/mine/7uy7) | Tetrahymena CST with Polymerase alpha-Primase | Descriptor: | DNA polymerase, Telomerase associated protein p50, Telomerase-associated protein of 19 kDa, ... | Authors: | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-05-06 | Release date: | 2022-07-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
|
|
7UY5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uy5 by Molmil](/molmil-images/mine/7uy5) | Tetrahymena telomerase with CST | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-05-06 | Release date: | 2022-07-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
|
|
7UY6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uy6 by Molmil](/molmil-images/mine/7uy6) | Tetrahymena telomerase at 2.9 Angstrom resolution | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-05-06 | Release date: | 2022-07-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
|
|
7UY8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uy8 by Molmil](/molmil-images/mine/7uy8) | Tetrahymena Polymerase alpha-Primase | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-05-06 | Release date: | 2022-07-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
|
|
8SNO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sno by Molmil](/molmil-images/mine/8sno) | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | Deposit date: | 2023-04-27 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 To Be Published
|
|
8SNL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8snl by Molmil](/molmil-images/mine/8snl) | Structure of human ADAM17/iRhom2 sheddase complex | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2, ... | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | Deposit date: | 2023-04-27 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Structure of human ADAM17/iRhom2 sheddase complex To Be Published
|
|
4H75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h75 by Molmil](/molmil-images/mine/4h75) | Crystal structure of human Spindlin1 in complex with a histone H3K4(me3) peptide | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Histone H3, ... | Authors: | Yang, N, Wang, W, Wang, Y, Wang, M, Zhao, Q, Rao, Z, Zhu, B, Xu, R.M. | Deposit date: | 2012-09-20 | Release date: | 2012-10-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4N76
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n76 by Molmil](/molmil-images/mine/4n76) | Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+ | Descriptor: | 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ... | Authors: | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | Deposit date: | 2013-10-15 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4OBY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4oby by Molmil](/molmil-images/mine/4oby) | Crystal Structure of E.coli Arginyl-tRNA Synthetase and Ligand Binding Studies Revealed Key Residues in Arginine Recognition | Descriptor: | ARGININE, Arginine--tRNA ligase | Authors: | Bi, K, Zheng, Y, Dong, J, Gao, F, Wang, J, Wang, Y, Gong, W. | Deposit date: | 2014-01-08 | Release date: | 2014-02-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.574 Å) | Cite: | Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition. Protein Cell, 5, 2014
|
|
4N41
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n41 by Molmil](/molmil-images/mine/4n41) | Structure of Thermus thermophilus Argonaute bound to guide DNA and 15-mer target DNA | Descriptor: | 5'-D(*AP*AP*CP*CP*TP*AP*CP*TP*GP*CP*CP*TP*CP*G)-3', 5'-D(P*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*T*GP*TP*AP*TP*AP*GP*T)-3', ... | Authors: | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | Deposit date: | 2013-10-08 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.248 Å) | Cite: | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4NCA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nca by Molmil](/molmil-images/mine/4nca) | Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+ | Descriptor: | 5'-D(*AP*CP*AP*AP*CP*C)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ... | Authors: | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | Deposit date: | 2013-10-24 | Release date: | 2014-01-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.489 Å) | Cite: | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
6LTP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ltp by Molmil](/molmil-images/mine/6ltp) | Crystal structure of Cas12i2 binary complex | Descriptor: | Cas12i2, crRNA (56-mer RNA) | Authors: | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | Deposit date: | 2020-01-23 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun, 11, 2020
|
|
1PCG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1pcg by Molmil](/molmil-images/mine/1pcg) | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions | Descriptor: | ESTRADIOL, estrogen receptor, peptide inhibitor | Authors: | Leduc, A.M, Trent, J.O, Wittliff, J.L, Bramlett, K.S, Briggs, S.L, Chirgadze, N.Y, Wang, Y, Burris, T.P, Spatola, A.F. | Deposit date: | 2003-05-16 | Release date: | 2003-10-28 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions Proc.Natl.Acad.Sci.USA, 100, 2003
|
|