6W7S
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![BU of 6w7s by Molmil](/molmil-images/mine/6w7s) | Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2G10 (Fab heavy chain), 2G10 (Fab light chain), ... | Authors: | Cogan, D.P, Mathews, I.I, Khosla, C. | Deposit date: | 2020-03-19 | Release date: | 2020-09-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. J.Am.Chem.Soc., 142, 2020
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6WH9
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![BU of 6wh9 by Molmil](/molmil-images/mine/6wh9) | Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10 | Descriptor: | 1D10 (Fab heavy chain), 1D10 (Fab light chain), KR1, ... | Authors: | Cogan, D.P, Mathews, I.I, Khosla, C. | Deposit date: | 2020-04-07 | Release date: | 2020-09-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. J.Am.Chem.Soc., 142, 2020
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5WA4
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![BU of 5wa4 by Molmil](/molmil-images/mine/5wa4) | |
5W98
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![BU of 5w98 by Molmil](/molmil-images/mine/5w98) | Pyridine synthase, PbtD, from GE2270 biosynthesis | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PbtD | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2017-06-22 | Release date: | 2017-11-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5W99
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![BU of 5w99 by Molmil](/molmil-images/mine/5w99) | Pyridine synthase, PbtD, from GE2270 biosynthesis bound to TSP | Descriptor: | 2,2'-(6-(2'-(aminomethyl)-[2,4'-bithiazol]-4-yl)pyridine-2,5-diyl)bis(thiazole-4-carboxylic acid), PbtD, SULFATE ION | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2017-06-22 | Release date: | 2017-11-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WA3
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![BU of 5wa3 by Molmil](/molmil-images/mine/5wa3) | |
6E6T
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![BU of 6e6t by Molmil](/molmil-images/mine/6e6t) | Dieckmann cyclase, NcmC, bound to cerulenin | Descriptor: | (4S,5R)-4,5-dihydroxy-5-[(3E,6E)-octa-3,6-dien-1-yl]pyrrolidin-2-one, NcmC, SULFATE ION | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. Acs Chem.Biol., 2020
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6C28
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![BU of 6c28 by Molmil](/molmil-images/mine/6c28) | Transcriptional repressor, CouR, bound to p-coumaroyl-CoA | Descriptor: | Transcriptional regulator, MarR family, p-coumaroyl-CoA | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-01-07 | Release date: | 2018-05-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris. J. Biol. Chem., 293, 2018
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6C2S
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![BU of 6c2s by Molmil](/molmil-images/mine/6c2s) | Transcriptional repressor, CouR, bound to a 23-mer DNA duplex | Descriptor: | 23-mer, Transcriptional regulator, MarR family | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-01-08 | Release date: | 2018-05-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris. J. Biol. Chem., 293, 2018
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6E6U
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![BU of 6e6u by Molmil](/molmil-images/mine/6e6u) | Variant C89S of Dieckmann cyclase, NcmC | Descriptor: | Dieckmann cyclase, NcmC, SULFATE ION | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. Acs Chem.Biol., 2020
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6E6Y
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![BU of 6e6y by Molmil](/molmil-images/mine/6e6y) | Dieckmann cyclase, NcmC | Descriptor: | Dieckmann cyclase, NcmC, SULFATE ION | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. Acs Chem.Biol., 2020
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6C9T
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![BU of 6c9t by Molmil](/molmil-images/mine/6c9t) | Transcriptional repressor, CouR | Descriptor: | CouR | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-01-28 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris. J. Biol. Chem., 293, 2018
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8TKO
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![BU of 8tko by Molmil](/molmil-images/mine/8tko) | KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its translocation ACP partner of Module 2 | Descriptor: | EryAI, EryAII | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-25 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TJO
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![BU of 8tjo by Molmil](/molmil-images/mine/8tjo) | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1 | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-23 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TJP
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![BU of 8tjp by Molmil](/molmil-images/mine/8tjp) | KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner | Descriptor: | EryAII | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-23 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TJN
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![BU of 8tjn by Molmil](/molmil-images/mine/8tjn) | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-23 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TPX
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![BU of 8tpx by Molmil](/molmil-images/mine/8tpx) | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-08-05 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TPW
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![BU of 8tpw by Molmil](/molmil-images/mine/8tpw) | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-08-05 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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7RC3
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![BU of 7rc3 by Molmil](/molmil-images/mine/7rc3) | Aeronamide N-methyltransferase, AerE (Y137F) | Descriptor: | ASPARTIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC4
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![BU of 7rc4 by Molmil](/molmil-images/mine/7rc4) | Aeronamide N-methyltransferase, AerE (D141A) | Descriptor: | CALCIUM ION, HEXAETHYLENE GLYCOL, Methyltransferase family protein, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC6
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![BU of 7rc6 by Molmil](/molmil-images/mine/7rc6) | Aeronamide N-methyltransferase, AerE, bound to modified peptide substrate, AerA-DL,34 | Descriptor: | Aeronamide A peptide, Methyltransferase family protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC2
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![BU of 7rc2 by Molmil](/molmil-images/mine/7rc2) | Aeronamide N-methyltransferase, AerE | Descriptor: | CALCIUM ION, Methyltransferase family protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC5
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![BU of 7rc5 by Molmil](/molmil-images/mine/7rc5) | Aeronamide N-methyltransferase, AerE (N231A) | Descriptor: | CALCIUM ION, Methyltransferase family protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7M7E
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![BU of 7m7e by Molmil](/molmil-images/mine/7m7e) | 6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2 | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), 6-deoxyerythronolide-B synthase EryA2, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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7M7H
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![BU of 7m7h by Molmil](/molmil-images/mine/7m7h) | 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1' | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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