7M7E

6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2

Summary for 7M7E

• Entry DOI: 10.2210/pdb7m7e/pdb
• EMDB information: 23710 23711 23712 23713 23714 23715
• Descriptor: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4,EryAI,6-deoxyerythronolide-B synthase EryA3, modules 5 and 6 chimera, 1B2 (heavy chain), 1B2 (light chain) (3 entities in total)
• Functional Keywords: polyketide synthase, antibody fragment, biosynthetic protein-immune system complex, biosynthetic protein/immune system
• Biological source: Saccharopolyspora erythraea (Streptomyces erythraeus); More
• Total number of polymer chains: 4
• Total formula weight: 427834.29

Authors

Cogan, D.P.,Zhang, K.,Chiu, W.,Khosla, C. (deposition date: 2021-03-28, release date: 2021-11-17)

• Primary citation: Cogan, D.P.,Zhang, K.,Li, X.,Li, S.,Pintilie, G.D.,Roh, S.H.,Craik, C.S.,Chiu, W.,Khosla, C.; Mapping the catalytic conformations of an assembly-line polyketide synthase module.; Science, 374:729-734, 2021; PubMed: 34735239; DOI: 10.1126/science.abi8358

Experimental method

ELECTRON MICROSCOPY (3.2 Å)