5WA4

Pyridine synthase, TbtD, from thiomuracin biosynthesis bound to an N-terminal leader peptide fragment

Summary for 5WA4

Entry DOI	10.2210/pdb5wa4/pdb
Descriptor	Pyridine synthase TbtD, TbtA 16-mer peptide (3 entities in total)
Functional Keywords	pyridine synthase, diels-alder, thiopeptide, thiomuracin, biosynthetic protein
Biological source	Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51) More
Total number of polymer chains	12
Total formula weight	252873.47
Authors	Cogan, D.P.,Nair, S.K. (deposition date: 2017-06-24, release date: 2017-11-22, Last modification date: 2023-10-04)
Primary citation	Cogan, D.P.,Hudson, G.A.,Zhang, Z.,Pogorelov, T.V.,van der Donk, W.A.,Mitchell, D.A.,Nair, S.K. Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 114:12928-12933, 2017 Cited by PubMed: 29158402 DOI: 10.1073/pnas.1716035114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.646 Å)

Structure validation