6WH9

Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10

Summary for 6WH9

Entry DOI	10.2210/pdb6wh9/pdb
Descriptor	KR1, 1D10 (Fab heavy chain), 1D10 (Fab light chain), ... (5 entities in total)
Functional Keywords	ketoreductase, antibody fragment, oxidoreductase-immune system complex, oxidoreductase/immune system
Biological source	Saccharopolyspora erythraea More
Total number of polymer chains	9
Total formula weight	305293.74
Authors	Cogan, D.P.,Mathews, I.I.,Khosla, C. (deposition date: 2020-04-07, release date: 2020-09-09, Last modification date: 2023-10-18)
Primary citation	Cogan, D.P.,Li, X.,Sevillano, N.,Mathews, I.I.,Matsui, T.,Craik, C.S.,Khosla, C. Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. J.Am.Chem.Soc., 142:14933-14939, 2020 Cited by PubMed: 32786753 DOI: 10.1021/jacs.0c05133 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation