6WH9
Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 G 2001 |
| Chain | Residue |
| C | SER110 |
| G | ARG1698 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 E 301 |
| Chain | Residue |
| E | SER27 |
| E | GLY28 |
| E | GLY29 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 F 301 |
| Chain | Residue |
| F | GLN59 |
| F | ARG62 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| B | GLY29 |
| B | SER27 |
| B | GLY28 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 301 |
| Chain | Residue |
| B | HIS174 |
| C | GLN186 |
| C | SER187 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 2001 |
| Chain | Residue |
| D | ARG1698 |
| D | ALA1753 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 2001 |
| Chain | Residue |
| A | SER1697 |
| A | ARG1698 |
| I | SER110 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 354 |
| Details | Region: {"description":"Beta-ketoacyl reductase 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"For beta-ketoacyl reductase 1 activity","evidences":[{"source":"UniProtKB","id":"Q03132","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"16564177","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16564177","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Could be the principal determinant of stereospecificity","evidences":[{"source":"PubMed","id":"16564177","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
