8SPF
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![BU of 8spf by Molmil](/molmil-images/mine/8spf) | Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC | Descriptor: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, DODECANE, ... | Authors: | Cowan, A.D, Miller, M.S, Czabotar, P.E, Colman, P.M. | Deposit date: | 2023-05-03 | Release date: | 2023-12-27 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291, 2024
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8SRX
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![BU of 8srx by Molmil](/molmil-images/mine/8srx) | Crystal structure of BAK-BAX heterodimer with lysoPC | Descriptor: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ... | Authors: | Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. | Deposit date: | 2023-05-07 | Release date: | 2023-12-27 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291, 2024
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8SRY
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![BU of 8sry by Molmil](/molmil-images/mine/8sry) | Crystal structure of BAK-BAX heterodimer with C12E8 | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ... | Authors: | Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. | Deposit date: | 2023-05-08 | Release date: | 2023-12-27 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291, 2024
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5GUT
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![BU of 5gut by Molmil](/molmil-images/mine/5gut) | The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A | Descriptor: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Chen, S.J, Ye, F. | Deposit date: | 2016-08-31 | Release date: | 2017-09-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
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5GUV
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![BU of 5guv by Molmil](/molmil-images/mine/5guv) | The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D | Descriptor: | DNA (cytosine-5)-methyltransferase 1, ZINC ION | Authors: | Ye, F, Chen, S.J. | Deposit date: | 2016-08-31 | Release date: | 2017-08-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.078 Å) | Cite: | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
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5GON
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![BU of 5gon by Molmil](/molmil-images/mine/5gon) | Structures of a beta-lactam bridged analogue in complex with tubulin | Descriptor: | (3R,4R)-4-(4-methoxy-3-oxidanyl-phenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Zhou, L, Liu, Y, Cheng, L, Wang, Y. | Deposit date: | 2016-07-28 | Release date: | 2017-03-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin. J. Med. Chem., 59, 2016
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6BOZ
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![BU of 6boz by Molmil](/molmil-images/mine/6boz) | Structure of human SETD8 in complex with covalent inhibitor MS4138 | Descriptor: | 1,2-ETHANEDIOL, N-(3-{[7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)prop-2-enamide, N-lysine methyltransferase KMT5A | Authors: | Babault, N, Anqi, M, Jin, J. | Deposit date: | 2017-11-21 | Release date: | 2019-05-01 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The dynamic conformational landscape of the protein methyltransferase SETD8. Elife, 8, 2019
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1QA7
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![BU of 1qa7 by Molmil](/molmil-images/mine/1qa7) | CRYSTAL COMPLEX OF THE 3C PROTEINASE FROM HEPATITIS A VIRUS WITH ITS INHIBITOR AND IMPLICATIONS FOR THE POLYPROTEIN PROCESSING IN HAV | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, HAV 3C PROTEINASE, ... | Authors: | Bergmann, E.M, Cherney, M.M, Mckendrick, J, Vederas, J.C, James, M.N.G. | Deposit date: | 1999-04-15 | Release date: | 1999-04-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV. Virology, 265, 1999
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8XYZ
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![BU of 8xyz by Molmil](/molmil-images/mine/8xyz) | The structure of fox ACE2 and PT RBD complex | Descriptor: | Angiotensin-converting enzyme, Signal peptide, Spike protein S1, ... | Authors: | sun, J.Q. | Deposit date: | 2024-01-20 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses. Virol Sin, 2024
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8XZB
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![BU of 8xzb by Molmil](/molmil-images/mine/8xzb) | The structure of fox ACE2 and SARS-CoV RBD complex | Descriptor: | Angiotensin-converting enzyme, Spike protein S1, ZINC ION | Authors: | sun, J.Q. | Deposit date: | 2024-01-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses. Virol Sin, 2024
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8XZD
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![BU of 8xzd by Molmil](/molmil-images/mine/8xzd) | The structure of fox ACE2 and Omicron BF.7 RBD complex | Descriptor: | Angiotensin-converting enzyme, Spike protein S1, ZINC ION | Authors: | sun, J.Q. | Deposit date: | 2024-01-21 | Release date: | 2024-06-12 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses. Virol Sin, 2024
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8WOY
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![BU of 8woy by Molmil](/molmil-images/mine/8woy) | Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 RBD in complex with rabbit ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1, ... | Authors: | Li, L.J, Shi, K.Y, Yu, G.H, Gao, G.F. | Deposit date: | 2023-10-08 | Release date: | 2023-12-13 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency. Mbio, 15, 2024
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8WOZ
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![BU of 8woz by Molmil](/molmil-images/mine/8woz) | Cryo-EM structure of SARS-CoV RBD in complex with rabbit ACE2 | Descriptor: | Angiotensin-converting enzyme, Spike protein S1, ZINC ION | Authors: | Li, L.J, Shi, K.Y, Yu, G.H, Gao, G.F. | Deposit date: | 2023-10-08 | Release date: | 2023-12-13 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency. Mbio, 15, 2024
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8WOX
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![BU of 8wox by Molmil](/molmil-images/mine/8wox) | Cryo-EM structure of SARS-CoV-2 prototype RBD in complex with rabbit ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1, ... | Authors: | Li, L.J, Shi, K.Y, Yu, G.H, Gao, G.F. | Deposit date: | 2023-10-08 | Release date: | 2023-12-13 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency. Mbio, 15, 2024
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3JVS
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![BU of 3jvs by Molmil](/molmil-images/mine/3jvs) | Characterization of the Chk1 allosteric inhibitor binding site | Descriptor: | 2-[(4-tert-butyl-3-nitrophenyl)carbonyl]-N-naphthalen-1-ylhydrazinecarboxamide, Serine/threonine-protein kinase Chk1 | Authors: | Chen, P. | Deposit date: | 2009-09-17 | Release date: | 2009-10-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of the CHK1 allosteric inhibitor binding site. Biochemistry, 48, 2009
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3JVR
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![BU of 3jvr by Molmil](/molmil-images/mine/3jvr) | Characterization of the Chk1 allosteric inhibitor binding site | Descriptor: | (1S)-1-(1H-benzimidazol-2-yl)ethyl (3,4-dichlorophenyl)carbamate, Serine/threonine-protein kinase Chk1 | Authors: | Chen, P. | Deposit date: | 2009-09-17 | Release date: | 2009-10-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Characterization of the CHK1 allosteric inhibitor binding site. Biochemistry, 48, 2009
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5D9Y
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![BU of 5d9y by Molmil](/molmil-images/mine/5d9y) | Crystal structure of TET2-5fC complex | Descriptor: | DNA (5'-D(*AP*CP*TP*GP*TP*(5FC)P*GP*AP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*TP*CP*GP*AP*CP*AP*GP*T)-3'), FE (III) ION, ... | Authors: | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | Deposit date: | 2015-08-19 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.971 Å) | Cite: | Structural insight into substrate preference for TET-mediated oxidation. Nature, 527, 2015
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7DNJ
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![BU of 7dnj by Molmil](/molmil-images/mine/7dnj) | K63-polyUb MDA5CARDs complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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7DNI
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![BU of 7dni by Molmil](/molmil-images/mine/7dni) | MDA5 CARDs-MAVS CARD polyUb complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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5ZAT
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![BU of 5zat by Molmil](/molmil-images/mine/5zat) | Crystal structure of 5-carboxylcytosine containing decamer dsDNA | Descriptor: | DNA (5'-D(*CP*CP*AP*GP*(CAC)P*GP*CP*TP*GP*G)-3') | Authors: | Fu, T.R, Zhang, L. | Deposit date: | 2018-02-08 | Release date: | 2019-02-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine. Chem Sci, 10, 2019
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5ZAS
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![BU of 5zas by Molmil](/molmil-images/mine/5zas) | Crystal structure of 5-formylcytosine containing decamer dsDNA | Descriptor: | BICARBONATE ION, DNA (5'-D(*CP*CP*AP*GP*(5FC)P*GP*CP*TP*GP*G)-3') | Authors: | Fu, T.R, Zhang, L. | Deposit date: | 2018-02-08 | Release date: | 2019-02-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine. Chem Sci, 10, 2019
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5ZBZ
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![BU of 5zbz by Molmil](/molmil-images/mine/5zbz) | Crystal structure of the DEAD domain of Human eIF4A with sanguinarine | Descriptor: | 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium, Eukaryotic initiation factor 4A-I, MALONATE ION | Authors: | Ding, Y, Ding, L. | Deposit date: | 2018-02-14 | Release date: | 2019-02-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.30860257 Å) | Cite: | Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling. Cell Chem Biol, 26, 2019
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7U72
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![BU of 7u72 by Molmil](/molmil-images/mine/7u72) | |
7U76
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![BU of 7u76 by Molmil](/molmil-images/mine/7u76) | |
7U7C
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![BU of 7u7c by Molmil](/molmil-images/mine/7u7c) | |