5GON
Structures of a beta-lactam bridged analogue in complex with tubulin
Summary for 5GON
Entry DOI | 10.2210/pdb5gon/pdb |
Related | 4O2B |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3R,4R)-4-(4-methoxy-3-oxidanyl-phenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, ... (13 entities in total) |
Functional Keywords | beta-lactam bridged analogue tubulin colchicine binding site, structural protein |
Biological source | Gallus gallus (Chicken) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 258402.97 |
Authors | |
Primary citation | Zhou, P.,Liu, Y.,Zhou, L.,Zhu, K.,Feng, K.,Zhang, H.,Liang, Y.,Jiang, H.,Luo, C.,Liu, M.,Wang, Y. Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin. J. Med. Chem., 59:10329-10334, 2016 Cited by PubMed: 27805821DOI: 10.1021/acs.jmedchem.6b01268 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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