5H17
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![BU of 5h17 by Molmil](/molmil-images/mine/5h17) | EED in complex with PRC2 allosteric inhibitor EED210 | Descriptor: | (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | Authors: | Zhao, K, Zhao, M, Luo, X, Zhang, H. | Deposit date: | 2016-10-08 | Release date: | 2017-01-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE, 12, 2017
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7QJU
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![BU of 7qju by Molmil](/molmil-images/mine/7qju) | EED in complex with PRC2 allosteric inhibitor compound 7 | Descriptor: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | Authors: | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | Deposit date: | 2021-12-17 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
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7QJG
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![BU of 7qjg by Molmil](/molmil-images/mine/7qjg) | EED in complex with PRC2 allosteric inhibitor compound 6 | Descriptor: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | Authors: | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | Deposit date: | 2021-12-16 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
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7QK4
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![BU of 7qk4 by Molmil](/molmil-images/mine/7qk4) | EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | Descriptor: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | Authors: | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | Deposit date: | 2021-12-17 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.602 Å) | Cite: | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
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1P33
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![BU of 1p33 by Molmil](/molmil-images/mine/1p33) | Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX | Descriptor: | METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | Authors: | Zhao, H, Bray, T, Ouellette, M, Zhao, M, Ferre, R.A, Matthews, D, Whiteley, J.M, Varughese, K.I. | Deposit date: | 2003-04-16 | Release date: | 2003-09-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Structure of pteridine reductase (PTR1) from Leishmania tarentolae. Acta Crystallogr.,Sect.D, 59, 2003
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1J73
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![BU of 1j73 by Molmil](/molmil-images/mine/1j73) | Crystal structure of an unstable insulin analog with native activity. | Descriptor: | ZINC ION, insulin a, insulin b | Authors: | Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A. | Deposit date: | 2001-05-15 | Release date: | 2001-05-30 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor. J.Mol.Biol., 315, 2002
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1JCA
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![BU of 1jca by Molmil](/molmil-images/mine/1jca) | Non-standard Design of Unstable Insulin Analogues with Enhanced Activity | Descriptor: | ZINC ION, insulin a, insulin b | Authors: | Weiss, M.A, Wan, Z, Zhao, M, Chu, Y.-C, Nakagawa, S.H, Burke, G.T, Jia, W, Hellmich, R, Katsoyannis, P.G. | Deposit date: | 2001-06-08 | Release date: | 2001-06-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor. J.Mol.Biol., 315, 2002
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2QVO
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![BU of 2qvo by Molmil](/molmil-images/mine/2qvo) | Crystal structure of AF1382 from Archaeoglobus fulgidus | Descriptor: | Uncharacterized protein AF_1382 | Authors: | Zhu, J, Zhao, M, Fu, Z.-Q, Yang, H, Chang, J, Hao, X, Chen, L, Liu, Z.J, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2007-08-08 | Release date: | 2007-09-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of AF1382 from Archaeoglobus fulgidus. To be Published
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5CCI
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![BU of 5cci by Molmil](/molmil-images/mine/5cci) | Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | Descriptor: | MAGNESIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Weis, W.I, Brunger, A.T. | Deposit date: | 2015-07-02 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature, 525, 2015
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5CCH
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![BU of 5cch by Molmil](/molmil-images/mine/5cch) | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | Deposit date: | 2015-07-02 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature, 525, 2015
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5CCG
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![BU of 5ccg by Molmil](/molmil-images/mine/5ccg) | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | Deposit date: | 2015-07-02 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature, 525, 2015
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5KJ7
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![BU of 5kj7 by Molmil](/molmil-images/mine/5kj7) | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from XFEL diffraction | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | Authors: | Lyubimov, A.Y, Uervirojnangkoorn, M, Zhou, Q, Zhao, M, Sauter, N.K, Brewster, A.S, Weis, W.I, Brunger, A.T. | Deposit date: | 2016-06-17 | Release date: | 2016-10-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex. Elife, 5, 2016
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6VHH
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![BU of 6vhh by Molmil](/molmil-images/mine/6vhh) | Human Teneurin-2 and human Latrophilin-3 binary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor L3, ... | Authors: | Xie, Y, Li, J, Arac, D, Zhao, M. | Deposit date: | 2020-01-09 | Release date: | 2020-06-03 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism. Nat Commun, 11, 2020
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5CCJ
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5KJ8
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![BU of 5kj8 by Molmil](/molmil-images/mine/5kj8) | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from synchrotron diffraction | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | Authors: | Lyubimov, A.Y, Uervirojnangkoorn, M, Zhou, Q, Zhao, M, Sauter, N.K, Brewster, A.S, Weis, W.I, Brunger, A.T. | Deposit date: | 2016-06-17 | Release date: | 2016-10-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex. Elife, 5, 2016
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6XOS
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![BU of 6xos by Molmil](/molmil-images/mine/6xos) | |
6XOU
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![BU of 6xou by Molmil](/molmil-images/mine/6xou) | |
6XOV
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![BU of 6xov by Molmil](/molmil-images/mine/6xov) | |
6XOT
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![BU of 6xot by Molmil](/molmil-images/mine/6xot) | |
8DMO
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![BU of 8dmo by Molmil](/molmil-images/mine/8dmo) | Structure of open, inward-facing MsbA from E. coli | Descriptor: | ATP-binding transport protein MsbA | Authors: | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | Deposit date: | 2022-07-08 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for lipid and copper regulation of the ABC transporter MsbA. Nat Commun, 13, 2022
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8DMM
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![BU of 8dmm by Molmil](/molmil-images/mine/8dmm) | Structure of the vanadate-trapped MsbA bound to KDL | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ADP ORTHOVANADATE, ATP-binding transport protein MsbA | Authors: | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | Deposit date: | 2022-07-08 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis for lipid and copper regulation of the ABC transporter MsbA. Nat Commun, 13, 2022
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8DZJ
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4EUE
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![BU of 4eue by Molmil](/molmil-images/mine/4eue) | Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Putative reductase CA_C0462, SODIUM ION | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-04-25 | Release date: | 2012-11-28 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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4EUF
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![BU of 4euf by Molmil](/molmil-images/mine/4euf) | Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative reductase CA_C0462, SODIUM ION | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-04-25 | Release date: | 2012-11-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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4EUH
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![BU of 4euh by Molmil](/molmil-images/mine/4euh) | Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase apo form | Descriptor: | Putative reductase CA_C0462, SODIUM ION | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-04-25 | Release date: | 2012-11-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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