1CA7
 
 | |
1CM9
 | |
1A15
 | | SDF-1ALPHA | | Descriptor: | STROMAL DERIVED FACTOR-1ALPHA, SULFATE ION | | Authors: | Dealwis, C.G, Fernandez, E.J, Lolis, E. | | Deposit date: | 1997-12-22 | | Release date: | 1998-08-12 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor.
Proc.Natl.Acad.Sci.USA, 95, 1998
|
|
1CGQ
 | |
5KW6
 | | Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base | | Descriptor: | DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | | Deposit date: | 2016-07-15 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
|
|
4GUM
 | | Cystal structure of locked-trimer of human MIF | | Descriptor: | CHLORIDE ION, Macrophage migration inhibitory factor | | Authors: | Fan, C, Lolis, E. | | Deposit date: | 2012-08-29 | | Release date: | 2013-07-03 | | Last modified: | 2020-11-18 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4PLU
 | |
4PKZ
 | |
5EIZ
 | |
8SPN
 | | Crystal structure of macrophage migration inhibitory factor in complex with T614 | | Descriptor: | GLYCEROL, ISOPROPYL ALCOHOL, Iguratimod, ... | | Authors: | Pantouris, G, Lolis, E. | | Deposit date: | 2023-05-03 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Mol Med, 30, 2024
|
|
5KW1
 | | Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue | | Descriptor: | CHLORIDE ION, DNA/RNA (30-MER), Poly(U)-binding-splicing factor PUF60 | | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | | Deposit date: | 2016-07-15 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
|
|
5KVY
 | | CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG | | Descriptor: | CHLORIDE ION, DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | | Authors: | Hsiao, H.-H, Crichlow, G.V, Albright, R.A, Murphy, J.W, Lolis, E.J, Braddock, D.T. | | Deposit date: | 2016-07-15 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
|
|
5KWQ
 | | Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60 | | Descriptor: | Poly(U)-binding-splicing factor PUF60 | | Authors: | Crichlow, G.V, Yang, Y, Zhou, H, Lolis, E.J, Braddock, D.T. | | Deposit date: | 2016-07-18 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
|
|
6OYB
 | |
6OYE
 | |
6OYG
 | |
6OY8
 | |
5UMJ
 | |
5UMK
 | |
4XX8
 | |
4XX7
 | |
7MRU
 | | Crystal structure of S62A MIF2 mutant | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase | | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | Deposit date: | 2021-05-09 | | Release date: | 2021-08-18 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
|
|
7MW7
 | | Crystal structure of P1G mutant of D-dopachrome tautomerase | | Descriptor: | D-dopachrome decarboxylase, SODIUM ION, SULFATE ION | | Authors: | Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E. | | Deposit date: | 2021-05-15 | | Release date: | 2021-08-18 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
|
|
7MSE
 | | High-resolution crystal structure of hMIF2 with tartrate at the active site | | Descriptor: | D-dopachrome decarboxylase, L(+)-TARTARIC ACID | | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | Deposit date: | 2021-05-11 | | Release date: | 2021-08-18 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
|
|
7MRV
 | | F100A mutant structure of MIF2 (D-DT) | | Descriptor: | D-dopachrome decarboxylase, SULFATE ION | | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | Deposit date: | 2021-05-09 | | Release date: | 2021-08-18 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
|
|
