8SPN

Crystal structure of macrophage migration inhibitory factor in complex with T614

Summary for 8SPN

Entry DOI	10.2210/pdb8spn/pdb
Descriptor	Macrophage migration inhibitory factor, SULFATE ION, ISOPROPYL ALCOHOL, ... (6 entities in total)
Functional Keywords	inhibitor, enzyme, complex, isomerase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	37783.85
Authors	Pantouris, G.,Lolis, E. (deposition date: 2023-05-03, release date: 2024-05-01)
Primary citation	Bloom, J.,Pantouris, G.,He, M.,Aljabari, B.,Mishra, L.,Manjula, R.,Parkins, A.,Lolis, E.J.,Al-Abed, Y. Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose. Mol Med, 30:43-43, 2024 Cited by PubMed Abstract: Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) overdose. Multiple small molecule inhibitors of MIF have been described, including the clinically available anti-rheumatic drug T-614 (iguratimod); however, this drug's mode of inhibition has not been fully investigated. PubMed: 38539088 DOI: 10.1186/s10020-024-00803-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation