4GUM

Cystal structure of locked-trimer of human MIF

Summary for 4GUM

Entry DOI	10.2210/pdb4gum/pdb
Descriptor	Macrophage migration inhibitory factor, CHLORIDE ION (3 entities in total)
Functional Keywords	alpha/beta mixture, cytokine and isomerase, isomerase
Biological source	Homo sapiens (Human)
Total number of polymer chains	9
Total formula weight	111380.49
Authors	Fan, C.,Lolis, E. (deposition date: 2012-08-29, release date: 2013-07-03, Last modification date: 2020-11-18)
Primary citation	Fan, C.,Rajasekaran, D.,Syed, M.A.,Leng, L.,Loria, J.P.,Bhandari, V.,Bucala, R.,Lolis, E.J. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc.Natl.Acad.Sci.USA, 110:10994-10999, 2013 Cited by PubMed: 23776208 DOI: 10.1073/pnas.1221817110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation