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4GUM

Cystal structure of locked-trimer of human MIF

Functional Information from GO Data
ChainGOidnamespacecontents
A0004167molecular_functiondopachrome isomerase activity
A0005125molecular_functioncytokine activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0016853molecular_functionisomerase activity
A0045087biological_processinnate immune response
A0050178molecular_functionphenylpyruvate tautomerase activity
B0004167molecular_functiondopachrome isomerase activity
B0005125molecular_functioncytokine activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0016853molecular_functionisomerase activity
B0045087biological_processinnate immune response
B0050178molecular_functionphenylpyruvate tautomerase activity
C0004167molecular_functiondopachrome isomerase activity
C0005125molecular_functioncytokine activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0006954biological_processinflammatory response
C0007165biological_processsignal transduction
C0016853molecular_functionisomerase activity
C0045087biological_processinnate immune response
C0050178molecular_functionphenylpyruvate tautomerase activity
D0004167molecular_functiondopachrome isomerase activity
D0005125molecular_functioncytokine activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0006954biological_processinflammatory response
D0007165biological_processsignal transduction
D0016853molecular_functionisomerase activity
D0045087biological_processinnate immune response
D0050178molecular_functionphenylpyruvate tautomerase activity
E0004167molecular_functiondopachrome isomerase activity
E0005125molecular_functioncytokine activity
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005737cellular_componentcytoplasm
E0006954biological_processinflammatory response
E0007165biological_processsignal transduction
E0016853molecular_functionisomerase activity
E0045087biological_processinnate immune response
E0050178molecular_functionphenylpyruvate tautomerase activity
F0004167molecular_functiondopachrome isomerase activity
F0005125molecular_functioncytokine activity
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005737cellular_componentcytoplasm
F0006954biological_processinflammatory response
F0007165biological_processsignal transduction
F0016853molecular_functionisomerase activity
F0045087biological_processinnate immune response
F0050178molecular_functionphenylpyruvate tautomerase activity
G0004167molecular_functiondopachrome isomerase activity
G0005125molecular_functioncytokine activity
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005737cellular_componentcytoplasm
G0006954biological_processinflammatory response
G0007165biological_processsignal transduction
G0016853molecular_functionisomerase activity
G0045087biological_processinnate immune response
G0050178molecular_functionphenylpyruvate tautomerase activity
H0004167molecular_functiondopachrome isomerase activity
H0005125molecular_functioncytokine activity
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005737cellular_componentcytoplasm
H0006954biological_processinflammatory response
H0007165biological_processsignal transduction
H0016853molecular_functionisomerase activity
H0045087biological_processinnate immune response
H0050178molecular_functionphenylpyruvate tautomerase activity
I0004167molecular_functiondopachrome isomerase activity
I0005125molecular_functioncytokine activity
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005737cellular_componentcytoplasm
I0006954biological_processinflammatory response
I0007165biological_processsignal transduction
I0016853molecular_functionisomerase activity
I0045087biological_processinnate immune response
I0050178molecular_functionphenylpyruvate tautomerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 201
ChainResidue
ALYS77

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL C 201
ChainResidue
CGLY17

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C 202
ChainResidue
CARG73
FGLY17
FLEU19

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL D 201
ChainResidue
AARG73
DGLY17
DLEU19

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL D 202
ChainResidue
DARG73
AGLY17

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL D 203
ChainResidue
BLYS32
DLYS77

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL E 201
ChainResidue
EASN102

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL I 201
ChainResidue
IGLY17
IARG73

Functional Information from PROSITE/UniProt
site_idPS01158
Number of Residues15
DetailsMIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG
ChainResidueDetails
AGLU54-GLY68

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsACT_SITE: Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884
ChainResidueDetails
APRO1
BPRO1
CPRO1
DPRO1
EPRO1
FPRO1
GPRO1
HPRO1
IPRO1

site_idSWS_FT_FI2
Number of Residues27
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14174
ChainResidueDetails
GLYS32
GILE64
GASN97
HLYS32
HILE64
HASN97
ILYS32
IILE64
IASN97
ALYS32
AILE64
AASN97
BLYS32
BILE64
BASN97
CLYS32
CILE64
CASN97
DLYS32
DILE64
DASN97
ELYS32
EILE64
EASN97
FLYS32
FILE64
FASN97

site_idSWS_FT_FI3
Number of Residues9
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884
ChainResidueDetails
ALYS77
BLYS77
CLYS77
DLYS77
ELYS77
FLYS77
GLYS77
HLYS77
ILYS77

220472

PDB entries from 2024-05-29

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