Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GUM

Cystal structure of locked-trimer of human MIF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004167	molecular_function	dopachrome isomerase activity
A	0005125	molecular_function	cytokine activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0007165	biological_process	signal transduction
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0080135	biological_process	regulation of cellular response to stress
B	0004167	molecular_function	dopachrome isomerase activity
B	0005125	molecular_function	cytokine activity
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0007165	biological_process	signal transduction
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0080135	biological_process	regulation of cellular response to stress
C	0004167	molecular_function	dopachrome isomerase activity
C	0005125	molecular_function	cytokine activity
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0007165	biological_process	signal transduction
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0080135	biological_process	regulation of cellular response to stress
D	0004167	molecular_function	dopachrome isomerase activity
D	0005125	molecular_function	cytokine activity
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0007165	biological_process	signal transduction
D	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0080135	biological_process	regulation of cellular response to stress
E	0004167	molecular_function	dopachrome isomerase activity
E	0005125	molecular_function	cytokine activity
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0007165	biological_process	signal transduction
E	0050178	molecular_function	phenylpyruvate tautomerase activity
E	0080135	biological_process	regulation of cellular response to stress
F	0004167	molecular_function	dopachrome isomerase activity
F	0005125	molecular_function	cytokine activity
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0007165	biological_process	signal transduction
F	0050178	molecular_function	phenylpyruvate tautomerase activity
F	0080135	biological_process	regulation of cellular response to stress
G	0004167	molecular_function	dopachrome isomerase activity
G	0005125	molecular_function	cytokine activity
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0007165	biological_process	signal transduction
G	0050178	molecular_function	phenylpyruvate tautomerase activity
G	0080135	biological_process	regulation of cellular response to stress
H	0004167	molecular_function	dopachrome isomerase activity
H	0005125	molecular_function	cytokine activity
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0007165	biological_process	signal transduction
H	0050178	molecular_function	phenylpyruvate tautomerase activity
H	0080135	biological_process	regulation of cellular response to stress
I	0004167	molecular_function	dopachrome isomerase activity
I	0005125	molecular_function	cytokine activity
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0007165	biological_process	signal transduction
I	0050178	molecular_function	phenylpyruvate tautomerase activity
I	0080135	biological_process	regulation of cellular response to stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 201

Chain	Residue
A	LYS77

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 201

Chain	Residue
C	GLY17

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 202

Chain	Residue
C	ARG73
F	GLY17
F	LEU19

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 201

Chain	Residue
A	ARG73
D	GLY17
D	LEU19

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 202

Chain	Residue
D	ARG73
A	GLY17

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 203

Chain	Residue
B	LYS32
D	LYS77

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 201

Chain	Residue
E	ASN102

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL I 201

Chain	Residue
I	GLY17
I	ARG73

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG

Chain	Residue	Details
A	GLU54-GLY68

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Active site: {"description":"Proton acceptor; via imino nitrogen","evidences":[{"source":"UniProtKB","id":"P34884","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14174","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P34884","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)