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HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:	2-OXOGLUTARIC ACID, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.46 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW2

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW3

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.279 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW4

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.528 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

5Y52

Crystal Structure of Highly Active BTUO Mutant P287G Improved by Humidity Control at 83% RH
Descriptor:	1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
Authors:	Itoh, T, Kishimoto, T, Nishiya, Y.
Deposit date:	2017-08-07
Release date:	2018-08-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.63 Å)
Cite:	Conformational Flexibility of Plastic Interface Loop Allows Entropic Adaptation of Urate Oxidase to Environmental pH To Be Published

5YJ2

Crystal structure of Bacillus sp. TB-90 urate oxidase without dehydration
Descriptor:	2-METHOXYETHANOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
Authors:	Hibi, T, Itoh, T, Nishiya, Y.
Deposit date:	2017-10-07
Release date:	2018-10-10
Last modified:	2018-12-19
Method:	X-RAY DIFFRACTION (1.71 Å)
Cite:	Crystal structure of Bacillus sp. TB-90 urate oxidase without dehydration To Be Published

5Y2P

Crystal Structure of Bacillus sp. TB-90 Urate Oxidase Improved by Humidity Control at 89% RH
Descriptor:	1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
Authors:	Itoh, T, Nishiya, Y.
Deposit date:	2017-07-26
Release date:	2018-08-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Conformational Flexibility of Plastic Interface Loop Allows Entropic Adaptation of Urate Oxidase to Environmental pH. To Be Published

5YJA

Crystal structure of highly active BTUO mutant P287G without dehydration
Descriptor:	2-METHOXYETHANOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
Authors:	Hibi, T, Itoh, T, Nishiya, Y.
Deposit date:	2017-10-09
Release date:	2018-10-10
Last modified:	2018-12-19
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase to be published

5Z2B

Crystal structure of highly active BTUO mutant P287G Improved by Humidity Control at 86% RH
Descriptor:	1,2-ETHANEDIOL, 8-AZAXANTHINE, CHLORIDE ION, ...
Authors:	Hibi, T, Itoh, T, Nishiya, Y.
Deposit date:	2018-01-02
Release date:	2019-01-02
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.901 Å)
Cite:	Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase to be published

4BQX

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	EGL NINE HOMOLOG 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2013-06-03
Release date:	2013-06-19
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem. Biol., 8, 2013

4BQW

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Descriptor:	2-[(1-methyl-2-oxidanyl-4-oxidanylidene-quinolin-3-yl)carbonylamino]ethanoic acid, EGL NINE HOMOLOG 1, MANGANESE (II) ION
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2013-06-03
Release date:	2013-06-19
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem. Biol., 8, 2013

5Z27

Crystal structure of highly active BTUO mutant P287G without dehydration
Descriptor:	1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
Authors:	Hibi, T, Itoh, T, Nishiya, Y.
Deposit date:	2017-12-29
Release date:	2019-01-02
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase to be published

4DO0

Crystal Structure of human PHF8 in complex with Daminozide
Descriptor:	1,2-ETHANEDIOL, ACETATE ION, DAMINOZIDE, ...
Authors:	Krojer, T, Daniel, M, Ng, S.S, Walport, L.J, Chowdhury, R, Arrowsmith, C.H, Edwards, A, Bountra, C, Kawamura, A, Muller-Knapp, S, McDonough, M.A, von Delft, F, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:	2012-02-09
Release date:	2012-03-14
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:

4AI9

JMJD2A Complexed with Daminozide
Descriptor:	CHLORIDE ION, DAMINOZIDE, GLYCEROL, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2012-02-08
Release date:	2012-10-03
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J. Med. Chem., 55, 2012

4BIS

JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
Descriptor:	8-hydroxyquinoline-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:	Chowdhury, R, Thinnes, C, Schofield, C.J.
Deposit date:	2013-04-12
Release date:	2014-02-05
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.493 Å)
Cite:	5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chem Sci, 4, 2013

4BIO

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID
Descriptor:	8-hydroxyquinoline-5-carboxylic acid, FE (III) ION, GLYCEROL, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2013-04-12
Release date:	2013-04-24
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chem Sci, 4, 2013

2YBK

JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
Descriptor:	(2R)-2-hydroxypentanedioic acid, CHLORIDE ION, LYSINE-SPECIFIC DEMETHYLASE 4A, ...
Authors:	Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:	2011-03-08
Release date:	2011-04-06
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

2YC0

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE
Descriptor:	(2R)-2-hydroxypentanedioic acid, FE (II) ION, GLYCEROL, ...
Authors:	Chowdhury, R, Clifton, I.J, Schofield, C.J.
Deposit date:	2011-03-10
Release date:	2011-03-30
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

2YBS

JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Descriptor:	(2S)-2-HYDROXYPENTANEDIOIC ACID, GLYCEROL, HISTONE H3.1T, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2011-03-10
Release date:	2011-03-30
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

2YDE

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE
Descriptor:	(2S)-2-HYDROXYPENTANEDIOIC ACID, FE (III) ION, GLYCEROL, ...
Authors:	Chowdhury, R, Clifton, I.J, Schofield, C.J.
Deposit date:	2011-03-18
Release date:	2011-03-30
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.28 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

2YBP

JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Descriptor:	(2R)-2-hydroxypentanedioic acid, GLYCEROL, HISTONE H3.1T, ...
Authors:	Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:	2011-03-09
Release date:	2011-03-30
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

5FWE

JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3me2s PEPTIDE
Descriptor:	CHLORIDE ION, GLYCEROL, LYSINE-SPECIFIC DEMETHYLASE 4A, ...
Authors:	Chowdhury, R, Walport, L.J, Schofield, C.J.
Deposit date:	2016-02-15
Release date:	2016-04-06
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Arginine Demethylation is Catalysed by a Subset of Jmjc Histone Lysine Demethylases. Nat.Commun., 7, 2016

5LAS

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.749 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

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