2YBK
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
Summary for 2YBK
Entry DOI | 10.2210/pdb2ybk/pdb |
Related | 2GF7 2GFA 2GP3 2GP5 2VD7 2WWJ 2YBP 2YBS |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 89232.43 |
Authors | Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2011-03-08, release date: 2011-04-06, Last modification date: 2023-12-20) |
Primary citation | Chowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12:463-469, 2011 Cited by PubMed: 21460794DOI: 10.1038/embor.2011.43 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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