4BIO

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID

Summary for 4BIO

• Entry DOI: 10.2210/pdb4bio/pdb
• Related: 4BIS
• Descriptor: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (III) ION, 8-hydroxyquinoline-5-carboxylic acid, ... (6 entities in total)
• Functional Keywords: oxidoreductase, dioxygenase, oxygenase, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 41704.25

Authors

Chowdhury, R.,Schofield, C.J. (deposition date: 2013-04-12, release date: 2013-04-24, Last modification date: 2023-12-20)

• Primary citation: Hopkinson, R.J.,Tumber, A.,Yapp, C.,Chowdhury, R.,Aik, W.,Che, K.H.,Li, X.S.,Kristensen, J.B.L.,King, O.N.F.,Chan, M.C.,Yeoh, K.K.,Choi, H.,Walport, L.J.,Thinnes, C.C.,Bush, J.T.,Lejeune, C.,Rydzik, A.M.,Rose, N.R.,Bagg, E.A.,McDonough, M.A.,Krojer, T.,Yue, W.W.,Ng, S.S.,Olsen, L.,Brennan, P.E.,Oppermann, U.,Muller-Knapp, S.,Klose, R.J.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.; 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.; Chem Sci, 4:3110-3117, 2013; PubMed: 26682036; DOI: 10.1039/C3SC51122G

Experimental method

X-RAY DIFFRACTION (2.45 Å)