4BQW

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

Summary for 4BQW

• Entry DOI: 10.2210/pdb4bqw/pdb
• Related: 4BQX 4BQY
• Descriptor: EGL NINE HOMOLOG 1, MANGANESE (II) ION, 2-[(1-methyl-2-oxidanyl-4-oxidanylidene-quinolin-3-yl)carbonylamino]ethanoic acid, ... (4 entities in total)
• Functional Keywords: oxidoreductase, 2-oxoglutarate, dioxygenase, egln, oxygenase, dna-binding, transcription, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 28428.12

Authors

Chowdhury, R.,Schofield, C.J. (deposition date: 2013-06-03, release date: 2013-06-19, Last modification date: 2023-12-20)

• Primary citation: Chowdhury, R.,Candela-Lena, J.I.,Chan, M.C.,Greenald, D.J.,Yeoh, K.K.,Tian, Y.M.,McDonough, M.A.,Tumber, A.,Rose, N.R.,Conejo-Garcia, A.,Demetriades, M.,Mathavan, S.,Kawamura, A.,Lee, M.K.,van Eeden, F.,Pugh, C.W.,Ratcliffe, P.J.,Schofield, C.J.; Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.; ACS Chem. Biol., 8:1488-1496, 2013; PubMed: 23683440; DOI: 10.1021/cb400088q

Experimental method

X-RAY DIFFRACTION (1.79 Å)