4AI9

JMJD2A Complexed with Daminozide

Summary for 4AI9

• Entry DOI: 10.2210/pdb4ai9/pdb
• Related: 2GF7 2GFA 2GP3 2GP5 2VD7 2WWJ 2YBK 2YBP 2YBS
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase, dioxygenase, oxygenase, double-stranded beta helix, facial triad, epigenetic and transcription regulation, chromatin regulator, hydroxylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 89544.26

Authors

Chowdhury, R.,Schofield, C.J. (deposition date: 2012-02-08, release date: 2012-10-03, Last modification date: 2023-12-20)

• Primary citation: Rose, N.R.,Woon, E.C.,Tumber, A.,Walport, L.J.,Chowdhury, R.,Li, X.S.,King, O.N.,Lejeune, C.,Ng, S.S.,Krojer, T.,Chan, M.C.,Rydzik, A.M.,Hopkinson, R.J.,Che, K.H.,Daniel, M.,Strain-Damerell, C.,Gileadi, C.,Kochan, G.,Leung, I.K.,Dunford, J.,Yeoh, K.K.,Ratcliffe, P.J.,Burgess-Brown, N.,von Delft, F.,Muller, S.,Marsden, B.,Brennan, P.E.,McDonough, M.A.,Oppermann, U.,Klose, R.J.,Schofield, C.J.,Kawamura, A.; Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.; J. Med. Chem., 55:6639-6643, 2012; PubMed: 22724510; DOI: 10.1021/jm300677j

Experimental method

X-RAY DIFFRACTION (2.25 Å)