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2YC0

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE

Summary for 2YC0
Entry DOI10.2210/pdb2yc0/pdb
Related1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YDE
DescriptorHYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, (2R)-2-hydroxypentanedioic acid, ... (6 entities in total)
Functional Keywordsoxidoreductase, dioxygenase, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight41475.04
Authors
Chowdhury, R.,Clifton, I.J.,Schofield, C.J. (deposition date: 2011-03-10, release date: 2011-03-30, Last modification date: 2023-12-20)
Primary citationChowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12:463-469, 2011
Cited by
PubMed: 21460794
DOI: 10.1038/embor.2011.43
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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