2YC0

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE

Summary for 2YC0

Related2WA4 2W0X 2Y0I 2CGN 2WA3 2CGO 2YDE 1IZ3 1H2M 1MZE 1MZF 1YCI 1H2N 1H2K 2XUM 1H2L
DescriptorHYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, (2R)-2-hydroxypentanedioic acid, ... (6 entities in total)
Functional Keywordsoxidoreductase, dioxygenase, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight41475.04
Authors
Chowdhury, R.,Clifton, I.J.,Schofield, C.J. (deposition date: 2011-03-10, release date: 2011-03-30, Last modification date: 2019-02-06)
Primary citation
Chowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12:463-469, 2011
PubMed: 21460794 (PDB entries with the same primary citation)
DOI: 10.1038/embor.2011.43
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.259100 2.8% 8.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report