2WA4

FACTOR INHIBITING HIF-1 ALPHA WITH N,3-dihydroxybenzamide

Summary for 2WA4

Entry DOI	10.2210/pdb2wa4/pdb
Related	1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3
Descriptor	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, N,3-DIHYDROXYBENZAMIDE, ... (5 entities in total)
Functional Keywords	hydroxylase, dioxygenase, transcription, oxidoreductase, transcription activator/inhibitor, hypoxia
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: Q9NWT6
Total number of polymer chains	1
Total formula weight	40786.46
Authors	Conejo-Garcia, A.,Lienard, B.M.R.,Clifton, I.J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-02-02, release date: 2010-04-21, Last modification date: 2023-12-13)
Primary citation	Conejo-Garcia, A.,McDonough, M.A.,Loenarz, C.,McNeill, L.A.,Hewitson, K.S.,Ge, W.,Lienard, B.M.,Schofield, C.J.,Clifton, I.J. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 20:6125-6128, 2010 Cited by PubMed: 20822901 DOI: 10.1016/j.bmcl.2010.08.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation