1H2L

Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide

Summary for 1H2L

Entry DOI	10.2210/pdb1h2l/pdb
Related	1D7G 1H2K 1H2M 1H2N 1L8C 1LM8 1LQB
Descriptor	FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ... (6 entities in total)
Functional Keywords	transcription activator-inhibitor complex, transcription activator inhibitor complex, oxygenase, transcription, hypoxia, asparaginyl hydroxylase, hydroxylase, transcription activator/inhibitor
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm : Q16665
Total number of polymer chains	2
Total formula weight	45229.29
Authors	Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Schlemminger, I.,Seibel, J.F.,Schofield, C.J. (deposition date: 2002-08-12, release date: 2002-11-28, Last modification date: 2018-02-21)
Primary citation	Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Seibel, J.F.,Schlemminger, I.,Pugh, C.,Ratcliffe, P.,Schofield, C.J. Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha J.Biol.Chem., 278:1802-1806, 2003 Cited by PubMed: 12446723 DOI: 10.1074/JBC.C200644200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation