2JZI
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6XXV
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![BU of 6xxv by Molmil](/molmil-images/mine/6xxv) | Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 | Descriptor: | Antibody C57, Heavy Chain, Light Chain, ... | Authors: | Yang, C, Sesterhenn, F, Correia, B.E, Pojer, F. | Deposit date: | 2020-01-28 | Release date: | 2020-04-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.20116425 Å) | Cite: | De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
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4JOX
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4JP0
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5Z4Y
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5Z4Z
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5Z50
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![BU of 5z50 by Molmil](/molmil-images/mine/5z50) | Crystal structure of PaCysB regulatory domain | Descriptor: | Cys regulon transcriptional activator, GLYCEROL, SULFATE ION | Authors: | Yang, C, Liang, H, Gan, J. | Deposit date: | 2018-01-15 | Release date: | 2019-01-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa. Mol.Microbiol., 111, 2019
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5WYO
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![BU of 5wyo by Molmil](/molmil-images/mine/5wyo) | Solution structure of E.coli HdeA | Descriptor: | Acid stress chaperone HdeA | Authors: | Yang, C, Hu, Y, Jin, C. | Deposit date: | 2017-01-14 | Release date: | 2017-11-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Characterizations of the Interactions between Escherichia coli Periplasmic Chaperone HdeA and Its Native Substrates during Acid Stress Biochemistry, 56, 2017
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5ZF2
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![BU of 5zf2 by Molmil](/molmil-images/mine/5zf2) | Crystal structure of Trxlp from Edwardsiella tarda EIB202 | Descriptor: | SULFATE ION, Thioredoxin (H-type,TRX-H) | Authors: | Yang, C, Quan, S. | Deposit date: | 2018-03-02 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. Plos Pathog., 15, 2019
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7VWP
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![BU of 7vwp by Molmil](/molmil-images/mine/7vwp) | Structure of the flavin-dependent monooxygenase FlsO1 from the biosynthesis of fluostatinsin | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, FlsO1, PHOSPHATE ION, ... | Authors: | Zhang, Y, Yang, C, Zhang, L, Zhang, C. | Deposit date: | 2021-11-11 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation Nat Commun, 13, 2022
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7AYE
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![BU of 7aye by Molmil](/molmil-images/mine/7aye) | Crystal structure of the computationally designed chemically disruptable heterodimer LD6-MDM2 | Descriptor: | Isoform 11 of E3 ubiquitin-protein ligase Mdm2, Thiol:disulfide interchange protein DsbD | Authors: | Yang, C, Lau, K, Pojer, F, Correia, B.E. | Deposit date: | 2020-11-12 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | A rational blueprint for the design of chemically-controlled protein switches. Nat Commun, 12, 2021
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4UIS
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![BU of 4uis by Molmil](/molmil-images/mine/4uis) | The cryoEM structure of human gamma-Secretase complex | Descriptor: | GAMMA-SECRETASE, LYSOZYME | Authors: | Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y. | Deposit date: | 2015-04-03 | Release date: | 2015-06-10 | Last modified: | 2017-08-02 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural Basis of Human Gamma-Secretase Assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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5A63
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![BU of 5a63 by Molmil](/molmil-images/mine/5a63) | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y. | Deposit date: | 2015-06-24 | Release date: | 2015-08-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | An Atomic Structure of Human Gamma-Secretase Nature, 525, 2015
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6M49
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![BU of 6m49 by Molmil](/molmil-images/mine/6m49) | cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | Descriptor: | 25-HYDROXYCHOLESTEROL, Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | Authors: | Yan, R, Cao, P, Song, W, Qian, H, Du, X, Coates, H.W, Zhao, X, Li, Y, Gao, S, Gong, X, Liu, X, Sui, J, Lei, J, Yang, H, Brown, A.J, Zhou, Q, Yan, C, Yan, N. | Deposit date: | 2020-03-06 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science, 371, 2021
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7YMJ
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![BU of 7ymj by Molmil](/molmil-images/mine/7ymj) | Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin | Descriptor: | Nb6, Tamsulosin, alpha1A-adrenergic receptor | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-28 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YMH
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![BU of 7ymh by Molmil](/molmil-images/mine/7ymh) | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline | Descriptor: | Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-28 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YM8
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![BU of 7ym8 by Molmil](/molmil-images/mine/7ym8) | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | Descriptor: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-27 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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4DNV
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![BU of 4dnv by Molmil](/molmil-images/mine/4dnv) | Crystal structure of the W285F mutant of UVB-resistance protein UVR8 | Descriptor: | AT5g63860/MGI19_6 | Authors: | Wu, D, Hu, Q, Yan, Z, Chen, W, Yan, C, Zhang, J, Wang, J, Shi, Y. | Deposit date: | 2012-02-09 | Release date: | 2012-03-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Structural basis of ultraviolet-B perception by UVR8. Nature, 484, 2012
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4DNW
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![BU of 4dnw by Molmil](/molmil-images/mine/4dnw) | Crystal structure of UVB-resistance protein UVR8 | Descriptor: | AT5g63860/MGI19_6 | Authors: | Wu, D, Hu, Q, Yan, Z, Chen, W, Yan, C, Wang, J, Shi, Y. | Deposit date: | 2012-02-09 | Release date: | 2012-03-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.773 Å) | Cite: | Structural basis of ultraviolet-B perception by UVR8. Nature, 484, 2012
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4DNU
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![BU of 4dnu by Molmil](/molmil-images/mine/4dnu) | Crystal structure of the W285A mutant of UVB-resistance protein UVR8 | Descriptor: | AT5g63860/MGI19_6 | Authors: | Wu, D, Hu, Q, Yan, Z, Chen, W, Yan, C, Zhang, J, Wang, J, Shi, Y. | Deposit date: | 2012-02-09 | Release date: | 2012-03-07 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (1.764 Å) | Cite: | Structural basis of ultraviolet-B perception by UVR8. Nature, 484, 2012
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4R12
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![BU of 4r12 by Molmil](/molmil-images/mine/4r12) | Crystal structure of the gamma-secretase component Nicastrin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Xie, T, Yan, C, Zhou, R, Zhao, Y, Sun, L, Yang, G, Lu, P, Ma, D, Shi, Y. | Deposit date: | 2014-08-03 | Release date: | 2014-09-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of the gamma-secretase component nicastrin. Proc.Natl.Acad.Sci.USA, 111, 2014
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8WA2
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![BU of 8wa2 by Molmil](/molmil-images/mine/8wa2) | cryo-EM structure of native mastigonemes isolated from Chlamydomonas reinhardtii at 3.0 angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huang, J, Tao, H, Chen, J, Pan, J, Yan, C, Yan, N. | Deposit date: | 2023-09-06 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-guided discovery of protein and glycan components in native mastigonemes. Cell, 187, 2024
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6LT0
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![BU of 6lt0 by Molmil](/molmil-images/mine/6lt0) | cryo-EM structure of C9ORF72-SMCR8-WDR41 | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | Authors: | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | Deposit date: | 2020-01-21 | Release date: | 2020-04-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
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4RNG
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![BU of 4rng by Molmil](/molmil-images/mine/4rng) | Crystal structure of a bacterial homologue of SWEET transporters | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MtN3/saliva family, SULFATE ION | Authors: | Hu, Q, Wang, J, Yan, C, Yan, N. | Deposit date: | 2014-10-24 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of a bacterial homologue of SWEET transporters. Cell Res., 24, 2014
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3J8H
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![BU of 3j8h by Molmil](/molmil-images/mine/3j8h) | Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Yan, Z, Bai, X, Yan, C, Wu, J, Scheres, S.H.W, Shi, Y, Yan, N. | Deposit date: | 2014-10-26 | Release date: | 2014-12-10 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517, 2015
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