6LT0

cryo-EM structure of C9ORF72-SMCR8-WDR41

Summary for 6LT0

• Entry DOI: 10.2210/pdb6lt0/pdb
• EMDB information: 0966
• Descriptor: WD repeat-containing protein 41, Guanine nucleotide exchange protein SMCR8, Guanine nucleotide exchange C9orf72 (3 entities in total)
• Functional Keywords: als, ftd, gtpase, c9orf72, smcr8, wdr41, gap, gef, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 422648.75

Authors

Tang, D.,Sheng, J.,Xu, L.,Zhan, X.,Yan, C.,Qi, S. (deposition date: 2020-01-21, release date: 2020-04-15, Last modification date: 2024-03-27)

• Primary citation: Tang, D.,Sheng, J.,Xu, L.,Zhan, X.,Liu, J.,Jiang, H.,Shu, X.,Liu, X.,Zhang, T.,Jiang, L.,Zhou, C.,Li, W.,Cheng, W.,Li, Z.,Wang, K.,Lu, K.,Yan, C.,Qi, S.; Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.; Proc.Natl.Acad.Sci.USA, 117:9876-9883, 2020; PubMed: 32303654; DOI: 10.1073/pnas.2002110117

Experimental method

ELECTRON MICROSCOPY (3.2 Å)