Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LT0

cryo-EM structure of C9ORF72-SMCR8-WDR41

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0006914	biological_process	autophagy
A	0010506	biological_process	regulation of autophagy
A	0032045	cellular_component	guanyl-nucleotide exchange factor complex
A	0045920	biological_process	negative regulation of exocytosis
A	0050777	biological_process	negative regulation of immune response
B	0000785	cellular_component	chromatin
B	0004860	molecular_function	protein kinase inhibitor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0006914	biological_process	autophagy
B	0010506	biological_process	regulation of autophagy
B	0010629	biological_process	negative regulation of gene expression
B	0016242	biological_process	negative regulation of macroautophagy
B	0019901	molecular_function	protein kinase binding
B	0032008	biological_process	positive regulation of TOR signaling
B	0032045	cellular_component	guanyl-nucleotide exchange factor complex
B	0045920	biological_process	negative regulation of exocytosis
B	0050777	biological_process	negative regulation of immune response
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	1901098	biological_process	positive regulation of autophagosome maturation
B	1902902	biological_process	negative regulation of autophagosome assembly
B	1903432	biological_process	regulation of TORC1 signaling
B	1990316	cellular_component	Atg1/ULK1 kinase complex
C	0000932	cellular_component	P-body
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005768	cellular_component	endosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006897	biological_process	endocytosis
C	0006914	biological_process	autophagy
C	0010494	cellular_component	cytoplasmic stress granule
C	0010506	biological_process	regulation of autophagy
C	0016239	biological_process	positive regulation of macroautophagy
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0031267	molecular_function	small GTPase binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031965	cellular_component	nuclear membrane
C	0032045	cellular_component	guanyl-nucleotide exchange factor complex
C	0032880	biological_process	regulation of protein localization
C	0034063	biological_process	stress granule assembly
C	0043005	cellular_component	neuron projection
C	0043204	cellular_component	perikaryon
C	0044295	cellular_component	axonal growth cone
C	0044304	cellular_component	main axon
C	0044754	cellular_component	autolysosome
C	0048675	biological_process	axon extension
C	0061909	biological_process	autophagosome-lysosome fusion
C	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
C	0098693	biological_process	regulation of synaptic vesicle cycle
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099523	cellular_component	presynaptic cytosol
C	0110053	biological_process	regulation of actin filament organization
C	1902774	biological_process	late endosome to lysosome transport
C	1903432	biological_process	regulation of TORC1 signaling
C	1990316	cellular_component	Atg1/ULK1 kinase complex
C	2000785	biological_process	regulation of autophagosome assembly
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005096	molecular_function	GTPase activator activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005765	cellular_component	lysosomal membrane
D	0006914	biological_process	autophagy
D	0010506	biological_process	regulation of autophagy
D	0032045	cellular_component	guanyl-nucleotide exchange factor complex
D	0045920	biological_process	negative regulation of exocytosis
D	0050777	biological_process	negative regulation of immune response
E	0000785	cellular_component	chromatin
E	0004860	molecular_function	protein kinase inhibitor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005096	molecular_function	GTPase activator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006351	biological_process	DNA-templated transcription
E	0006914	biological_process	autophagy
E	0010506	biological_process	regulation of autophagy
E	0010629	biological_process	negative regulation of gene expression
E	0016242	biological_process	negative regulation of macroautophagy
E	0019901	molecular_function	protein kinase binding
E	0032008	biological_process	positive regulation of TOR signaling
E	0032045	cellular_component	guanyl-nucleotide exchange factor complex
E	0045920	biological_process	negative regulation of exocytosis
E	0050777	biological_process	negative regulation of immune response
E	0098793	cellular_component	presynapse
E	0098794	cellular_component	postsynapse
E	1901098	biological_process	positive regulation of autophagosome maturation
E	1902902	biological_process	negative regulation of autophagosome assembly
E	1903432	biological_process	regulation of TORC1 signaling
E	1990316	cellular_component	Atg1/ULK1 kinase complex
F	0000932	cellular_component	P-body
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005096	molecular_function	GTPase activator activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005768	cellular_component	endosome
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006897	biological_process	endocytosis
F	0006914	biological_process	autophagy
F	0010494	cellular_component	cytoplasmic stress granule
F	0010506	biological_process	regulation of autophagy
F	0016239	biological_process	positive regulation of macroautophagy
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0031267	molecular_function	small GTPase binding
F	0031410	cellular_component	cytoplasmic vesicle
F	0031965	cellular_component	nuclear membrane
F	0032045	cellular_component	guanyl-nucleotide exchange factor complex
F	0032880	biological_process	regulation of protein localization
F	0034063	biological_process	stress granule assembly
F	0043005	cellular_component	neuron projection
F	0043204	cellular_component	perikaryon
F	0044295	cellular_component	axonal growth cone
F	0044304	cellular_component	main axon
F	0044754	cellular_component	autolysosome
F	0048675	biological_process	axon extension
F	0061909	biological_process	autophagosome-lysosome fusion
F	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
F	0098693	biological_process	regulation of synaptic vesicle cycle
F	0098793	cellular_component	presynapse
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0099523	cellular_component	presynaptic cytosol
F	0110053	biological_process	regulation of actin filament organization
F	1902774	biological_process	late endosome to lysosome transport
F	1903432	biological_process	regulation of TORC1 signaling
F	1990316	cellular_component	Atg1/ULK1 kinase complex
F	2000785	biological_process	regulation of autophagosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ILTAsaDrTVIVWDG

Chain	Residue	Details
A	ILE106-GLY120
A	LEU337-LEU351

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	74
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	76
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	132
Details	Domain: {"description":"dDENN FLCN/SMCR8-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01178","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23248642","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	104
Details	Region: {"description":"Interacts with WDR41 within the C9orf72-SMCR8 complex","evidences":[{"source":"PubMed","id":"32303654","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by TBK1","evidences":[{"source":"PubMed","id":"27103069","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	188
Details	Domain: {"description":"dDENN C9ORF72-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01179","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)