7AYE

Crystal structure of the computationally designed chemically disruptable heterodimer LD6-MDM2

Summary for 7AYE

Entry DOI	10.2210/pdb7aye/pdb
Descriptor	Isoform 11 of E3 ubiquitin-protein ligase Mdm2, Thiol:disulfide interchange protein DsbD (2 entities in total)
Functional Keywords	chemically disruptable heterodimer (cdh), protein-protein interaction, gene and cell therapy, protein switches, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28722.63
Authors	Yang, C.,Lau, K.,Pojer, F.,Correia, B.E. (deposition date: 2020-11-12, release date: 2021-08-18, Last modification date: 2024-01-31)
Primary citation	Shui, S.,Gainza, P.,Scheller, L.,Yang, C.,Kurumida, Y.,Rosset, S.,Georgeon, S.,Di Roberto, R.B.,Castellanos-Rueda, R.,Reddy, S.T.,Correia, B.E. A rational blueprint for the design of chemically-controlled protein switches. Nat Commun, 12:5754-5754, 2021 Cited by PubMed: 34599176 DOI: 10.1038/s41467-021-25735-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation