6OEL
| Engineered Fab bound to IL-4 receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ... | Authors: | Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C. | Deposit date: | 2019-03-27 | Release date: | 2019-08-07 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A strategy for the selection of monovalent antibodies that span protein dimer interfaces. J.Biol.Chem., 294, 2019
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5UN6
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5UN5
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5UTZ
| Human IL-2/Fab complex | Descriptor: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | Authors: | Jude, K.M, Garcia, K.C. | Deposit date: | 2017-02-15 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.747 Å) | Cite: | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24, 2018
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1I1R
| CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX | Descriptor: | INTERLEUKIN-6 RECEPTOR BETA CHAIN, VIRAL IL-6 | Authors: | Chow, D, He, X, Snow, A.L, Rose-John, S, Garcia, K.C. | Deposit date: | 2001-02-02 | Release date: | 2001-03-28 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of an extracellular gp130 cytokine receptor signaling complex. Science, 291, 2001
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5WB1
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5WB2
| US28 bound to engineered chemokine CX3CL1.35 and nanobodies | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ... | Authors: | Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C. | Deposit date: | 2017-06-27 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife, 7, 2018
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8UOS
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8UPB
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8UPA
| Structure of gp130 in complex with a de novo designed IL-6 mimetic | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, De novo designed IL-6 mimetic, Interleukin-6 receptor subunit beta, ... | Authors: | Borowska, M.T, Jude, K.M, Garcia, K.C. | Deposit date: | 2023-10-22 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15, 2024
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5E4E
| Engineered Interleukin-13 bound to receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ... | Authors: | Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-10-05 | Release date: | 2015-12-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci.Signal., 8, 2015
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2Z31
| Crystal structure of immune receptor complex | Descriptor: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain precursor, ... | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-05-30 | Release date: | 2007-10-09 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat.Immunol., 8, 2007
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8FFE
| Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | Descriptor: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | Authors: | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | Deposit date: | 2022-12-08 | Release date: | 2023-03-08 | Last modified: | 2023-03-22 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
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8G04
| Structure of signaling thrombopoietin-MPL receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ... | Authors: | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | Deposit date: | 2023-01-31 | Release date: | 2023-08-30 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell, 186, 2023
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8FRE
| Designed loop protein RBL4 | Descriptor: | 1,2-ETHANEDIOL, RBL4 | Authors: | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | Deposit date: | 2023-01-06 | Release date: | 2024-04-17 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | De novo design of buttressed loops for sculpting protein functions. Nat.Chem.Biol., 20, 2024
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8FRF
| Homodimeric designed loop protein RBL7_C2_3 | Descriptor: | MALONATE ION, RBL7_C2_3 | Authors: | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | Deposit date: | 2023-01-06 | Release date: | 2024-04-17 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | De novo design of buttressed loops for sculpting protein functions. Nat.Chem.Biol., 20, 2024
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8FX4
| GC-C-Hsp90-Cdc37 regulatory complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Guanylyl cyclase C, Heat shock protein HSP 90-beta, ... | Authors: | Caveney, N.A, Garcia, K.C. | Deposit date: | 2023-01-23 | Release date: | 2023-07-12 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. Elife, 12, 2023
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5EO9
| Crystal Structure of the complex of Dpr6 Domain 1 bound to DIP-alpha Domain 1+2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CG32791, isoform A, ... | Authors: | Ozkan, E, Zinn, K, Garcia, K.C. | Deposit date: | 2015-11-10 | Release date: | 2016-01-06 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.2988 Å) | Cite: | Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell, 163, 2015
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2Z35
| Crystal structure of immune receptor | Descriptor: | T-cell receptor alpha-chain, T-cell receptor beta-chain | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-06-01 | Release date: | 2007-10-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon' Nat.Immunol., 8, 2007
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1KZQ
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1JDP
| Crystal Structure of Hormone/Receptor Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR, ... | Authors: | He, X.-L, Chow, D.-C, Martick, M.M, Garcia, K.C. | Deposit date: | 2001-06-14 | Release date: | 2001-09-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science, 293, 2001
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1K2D
| Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H-2 class II histocompatibility antigen, A-U alpha chain, ... | Authors: | He, X.L, Radu, C, Ward, E.S, Garcia, K.C. | Deposit date: | 2001-09-26 | Release date: | 2003-03-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural snapshot of aberrant antigen presentation linked to autoimmunity: the
immunodominant epitope of MBP complexed with I-Au IMMUNITY, 17, 2002
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1LEK
| Crystal Structure of H-2Kbm3 bound to dEV8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | Authors: | Luz, J.G, Huang, M, Garcia, K.C, Rudolph, M.G, Apostolopoulos, V, Teyton, L, Wilson, I.A. | Deposit date: | 2002-04-09 | Release date: | 2002-06-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J.Exp.Med., 195, 2002
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1LEG
| Crystal Structure of H-2Kb bound to the dEV8 peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-2-MICROGLOBULIN, ... | Authors: | Luz, J.G, Huang, M, Garcia, K.C, Rudolph, M.G, Apostolopoulos, V, Teyton, L, Wilson, I.A. | Deposit date: | 2002-04-09 | Release date: | 2002-06-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J.Exp.Med., 195, 2002
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1MWA
| 2C/H-2KBM3/DEV8 ALLOGENEIC COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2C T CELL RECEPTOR ALPHA CHAIN, ... | Authors: | Luz, J.G, Huang, M.D, Garcia, K.C, Rudolph, M.G, Teyton, L, Wilson, I.A. | Deposit date: | 2002-09-27 | Release date: | 2002-11-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility
complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially
increasing V(beta) Interactions. J.EXP.MED., 195, 2002
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