8G04

Structure of signaling thrombopoietin-MPL receptor complex

Summary for 8G04

• Entry DOI: 10.2210/pdb8g04/pdb
• EMDB information: 29644
• Descriptor: Thrombopoietin, Thrombopoietin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: tpo, tpor, cytokine, receptor, signaling, haematology
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 163776.40

Authors

Tsutsumi, N.,Jude, K.M.,Gati, C.,Garcia, K.C. (deposition date: 2023-01-31, release date: 2023-08-30)

• Primary citation: Tsutsumi, N.,Masoumi, Z.,James, S.C.,Tucker, J.A.,Winkelmann, H.,Grey, W.,Picton, L.K.,Moss, L.,Wilson, S.C.,Caveney, N.A.,Jude, K.M.,Gati, C.,Piehler, J.,Hitchcock, I.S.,Garcia, K.C.; Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis; Cell(Cambridge,Mass.), 186:1-15, 2023

Experimental method

ELECTRON MICROSCOPY (3.4 Å)