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8G04

Structure of signaling thrombopoietin-MPL receptor complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005179molecular_functionhormone activity
A0005576cellular_componentextracellular region
A0008283biological_processcell population proliferation
B0001780biological_processneutrophil homeostasis
B0004896molecular_functioncytokine receptor activity
B0005515molecular_functionprotein binding
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0007166biological_processcell surface receptor signaling pathway
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0016064biological_processimmunoglobulin mediated immune response
B0031965cellular_componentnuclear membrane
B0035702biological_processmonocyte homeostasis
B0038163biological_processthrombopoietin-mediated signaling pathway
B0038164molecular_functionthrombopoietin receptor activity
B0043025cellular_componentneuronal cell body
B0050671biological_processpositive regulation of lymphocyte proliferation
B0071456biological_processcellular response to hypoxia
B1905221biological_processpositive regulation of platelet formation
B1990959biological_processeosinophil homeostasis
B1990960biological_processbasophil homeostasis
C0001780biological_processneutrophil homeostasis
C0004896molecular_functioncytokine receptor activity
C0005515molecular_functionprotein binding
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0007166biological_processcell surface receptor signaling pathway
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0016020cellular_componentmembrane
C0016064biological_processimmunoglobulin mediated immune response
C0031965cellular_componentnuclear membrane
C0035702biological_processmonocyte homeostasis
C0038163biological_processthrombopoietin-mediated signaling pathway
C0038164molecular_functionthrombopoietin receptor activity
C0043025cellular_componentneuronal cell body
C0050671biological_processpositive regulation of lymphocyte proliferation
C0071456biological_processcellular response to hypoxia
C1905221biological_processpositive regulation of platelet formation
C1990959biological_processeosinophil homeostasis
C1990960biological_processbasophil homeostasis
Functional Information from PROSITE/UniProt
site_idPS00817
Number of Residues28
DetailsEPO_TPO Erythropoietin / thrombopoeitin signature. PappaCDlRVLsKllrdshvlhsrlsqC
ChainResidueDetails
APRO23-CYS50

site_idPS01352
Number of Residues78
DetailsHEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LeLeWqhpsswaaqetc....YQLrytgeghqdwkvlepplgarggtle..LrprsryrlqlRaRlngptyqgpWssWsdptrV
ChainResidueDetails
BLEU406-VAL483

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues930
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BPCA26-TRP491
CPCA26-TRP491

site_idSWS_FT_FI2
Number of Residues42
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BILE492-LEU513
CILE492-LEU513
ATHR179
ATHR180

site_idSWS_FT_FI3
Number of Residues242
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BARG514-PRO635
CARG514-PRO635

site_idSWS_FT_FI4
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN117
BASN178
BASN298
BASN358
CASN117
CASN178
CASN298
CASN358

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19880496
ChainResidueDetails
BLYS553
CLYS553

site_idSWS_FT_FI6
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
BLYS573
CLYS573

223532

PDB entries from 2024-08-07

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