8G04

Structure of signaling thrombopoietin-MPL receptor complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
A	0008283	biological_process	cell population proliferation
B	0001780	biological_process	neutrophil homeostasis
B	0004896	molecular_function	cytokine receptor activity
B	0005515	molecular_function	protein binding
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0016020	cellular_component	membrane
B	0030220	biological_process	platelet formation
B	0035702	biological_process	monocyte homeostasis
B	0038163	biological_process	thrombopoietin-mediated signaling pathway
B	0038164	molecular_function	thrombopoietin receptor activity
B	0043025	cellular_component	neuronal cell body
B	0050671	biological_process	positive regulation of lymphocyte proliferation
B	0071456	biological_process	cellular response to hypoxia
B	1903706	biological_process	regulation of hemopoiesis
B	1905221	biological_process	positive regulation of platelet formation
B	1990959	biological_process	eosinophil homeostasis
B	1990960	biological_process	basophil homeostasis
C	0001780	biological_process	neutrophil homeostasis
C	0004896	molecular_function	cytokine receptor activity
C	0005515	molecular_function	protein binding
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0016020	cellular_component	membrane
C	0030220	biological_process	platelet formation
C	0035702	biological_process	monocyte homeostasis
C	0038163	biological_process	thrombopoietin-mediated signaling pathway
C	0038164	molecular_function	thrombopoietin receptor activity
C	0043025	cellular_component	neuronal cell body
C	0050671	biological_process	positive regulation of lymphocyte proliferation
C	0071456	biological_process	cellular response to hypoxia
C	1903706	biological_process	regulation of hemopoiesis
C	1905221	biological_process	positive regulation of platelet formation
C	1990959	biological_process	eosinophil homeostasis
C	1990960	biological_process	basophil homeostasis

Functional Information from PROSITE/UniProt

site_id	PS00817
Number of Residues	28
Details	EPO_TPO Erythropoietin / thrombopoeitin signature. PappaCDlRVLsKllrdshvlhsrlsqC

Chain	Residue	Details
A	PRO23-CYS50

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site_id	PS01352
Number of Residues	78
Details	HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LeLeWqhpsswaaqetc....YQLrytgeghqdwkvlepplgarggtle..LrprsryrlqlRaRlngptyqgpWssWsdptrV

Chain	Residue	Details
B	LEU406-VAL483

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"8942648","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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