5UN5
Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1
Summary for 5UN5
Entry DOI | 10.2210/pdb5un5/pdb |
Related | 5UN6 |
Descriptor | Frizzled-8, Designed Wnt agonist B12 (3 entities in total) |
Functional Keywords | signaling protein, signaling protein-de novo protein complex, signaling protein/de novo protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Multi-pass membrane protein: Q9H461 |
Total number of polymer chains | 4 |
Total formula weight | 57572.24 |
Authors | Janda, C.Y.,Garcia, K.C. (deposition date: 2017-01-30, release date: 2017-05-03, Last modification date: 2023-10-04) |
Primary citation | Janda, C.Y.,Dang, L.T.,You, C.,Chang, J.,de Lau, W.,Zhong, Z.A.,Yan, K.S.,Marecic, O.,Siepe, D.,Li, X.,Moody, J.D.,Williams, B.O.,Clevers, H.,Piehler, J.,Baker, D.,Kuo, C.J.,Garcia, K.C. Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature, 545:234-237, 2017 Cited by PubMed: 28467818DOI: 10.1038/nature22306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.994 Å) |
Structure validation
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