5UN5

Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Frizzled-8	polymer	129	14961.1	2	UniProt (Q9H461) Pfam (PF01392)	Homo sapiens (Human)	hFz8
2	C, D (D, C)	Designed Wnt agonist B12	polymer	123	13825.0	2		synthetic construct
3	E, F (B, D)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

B, A: 1 - 123 (UniProt: Q9H461)

PDB	External Database	Details
Gln 22	Asn 49	conflict
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57572.2
All*	Total formula weight	57572.2

*Water molecules are not included.