8UOS
Designed IL-1R antagonist IL-1Rmb80
Summary for 8UOS
Entry DOI | 10.2210/pdb8uos/pdb |
Descriptor | IL-1Rmb80, GLYCEROL (3 entities in total) |
Functional Keywords | protein design, antagonist, immune system, de novo protein |
Biological source | synthetic construct |
Total number of polymer chains | 4 |
Total formula weight | 30945.72 |
Authors | |
Primary citation | Huang, B.,Coventry, B.,Borowska, M.T.,Arhontoulis, D.C.,Exposit, M.,Abedi, M.,Jude, K.M.,Halabiya, S.F.,Allen, A.,Cordray, C.,Goreshnik, I.,Ahlrichs, M.,Chan, S.,Tunggal, H.,DeWitt, M.,Hyams, N.,Carter, L.,Stewart, L.,Fuller, D.H.,Mei, Y.,Garcia, K.C.,Baker, D. De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15:7064-7064, 2024 Cited by PubMed: 39152100DOI: 10.1038/s41467-024-50919-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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