8FFE

Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide

Summary for 8FFE

• Entry DOI: 10.2210/pdb8ffe/pdb
• Related: 8CTG
• EMDB information: 26989
• Descriptor: Low-density lipoprotein receptor-related protein 6, YW210.09 Fab heavy chain with engineered XWnt8 NC peptide and linker, YW210.09 Fab light chain, ... (10 entities in total)
• Functional Keywords: wnt, receptor, lrp5, lrp6, ldl receptor-like protein, ywtd b-propeller, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 125399.74

Authors

Jude, K.M.,Tsutsumi, N.,Waghray, D.,Garcia, K.C. (deposition date: 2022-12-08, release date: 2023-03-08, Last modification date: 2023-03-22)

• Primary citation: Tsutsumi, N.,Hwang, S.,Waghray, D.,Hansen, S.,Jude, K.M.,Wang, N.,Miao, Y.,Glassman, C.R.,Caveney, N.A.,Janda, C.Y.,Hannoush, R.N.,Garcia, K.C.; Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.; Proc.Natl.Acad.Sci.USA, 120:e2218238120-e2218238120, 2023; PubMed: 36893265; DOI: 10.1073/pnas.2218238120

Experimental method

X-RAY DIFFRACTION (1.72 Å)