8FFE
Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Low-density lipoprotein receptor-related protein 6 | polymer | 613 | 69302.1 | 1 | UniProt (O75581) Pfam (PF00058) Pfam (PF14670) In PDB | Homo sapiens (human) | LRP-6 |
| 2 | H | YW210.09 Fab heavy chain with engineered XWnt8 NC peptide and linker | polymer | 276 | 28657.8 | 1 | Homo sapiens | ||
| 3 | L | YW210.09 Fab light chain | polymer | 225 | 24426.0 | 1 | Homo sapiens | ||
| 4 | B | alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 716.7 | 1 | In PDB GlyTouCan (G63564LA) | |||
| 5 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 878.8 | 1 | In PDB GlyTouCan (G92953ND) | |||
| 6 | D | alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB | |||
| 7 | A, H, L | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 8 | A | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 9 | L | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) | |||
| 10 | water | water | 18.0 | 592 | Chemie (HOH) |
Sequence modifications
A: 20 - 631 (UniProt: O75581)
| PDB | External Database | Details |
|---|---|---|
| His 632 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 122386.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2182.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 831.7 | |
| All* | Total formula weight | 125399.7 |
