Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A

Summary for 1K2D

DescriptorH-2 class II histocompatibility antigen, A-U alpha chain, H-2 class II histocompatibility antigen, A-U beta chain, Myelin Basic Protein peptide with 8 residue linker peptide, ... (6 entities in total)
Functional Keywordsmhc class ii, i-au, h-2u, autoimmune disease, unique register, experimental autoimmune encephalomyelitis, myelin basic protein, immune system
Biological sourceMus musculus (house mouse)
Cellular locationMembrane; Single-pass type I membrane protein (Potential) P14438 P06344
Total number of polymer chains3
Total molecular weight46946.99
He, X.L.,Radu, C.,Ward, E.S.,Garcia, K.C. (deposition date: 2001-09-26, release date: 2003-03-04, Last modification date: 2011-07-13)
Primary citation
He, X.L.,Radu, C.,Sidney, J.,Sette, A.,Ward, E.S.,Garcia, K.C.
Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au
IMMUNITY, 17:83-94, 2002
PubMed: 12150894 (PDB entries with the same primary citation)
DOI: 10.1016/S1074-7613(02)00340-0
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers221.1%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1k2d
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Molmil generated image of 1k2d
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