1K2D
Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | H-2 class II histocompatibility antigen, A-U alpha chain | polymer | 189 | 21468.8 | 1 | UniProt (P14438) Pfam (PF00993) Pfam (PF07654) In PDB | Mus musculus (house mouse) | MHC CLASS II I-AU |
2 | B | H-2 class II histocompatibility antigen, A-U beta chain | polymer | 189 | 22495.2 | 1 | UniProt (P06344) Pfam (PF00969) Pfam (PF07654) In PDB | Mus musculus (house mouse) | MHC CLASS II I-AU |
3 | P | Myelin Basic Protein peptide with 8 residue linker peptide | polymer | 23 | 2319.4 | 1 | GenBank (14763906) UniProt (by SIFTS) (P02686) In PDB | MBP peptide | |
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
5 | water | water | 18.0 | 450 | Chemie (HOH) |
Sequence modifications
A: 4 - 181 (UniProt: P14438)
P: 0 - 10 (GenBank: 14763906)
PDB | External Database | Details |
---|---|---|
His -6 | - | cloning artifact |
Ser -5 | - | cloning artifact |
Arg -4 | - | cloning artifact |
Gly -3 | - | cloning artifact |
Glu -2 | - | cloning artifact |
Asp -1 | - | cloning artifact |
Asp 0 | - | cloning artifact |
Ile 1 | - | cloning artifact |
Glu 2 | - | cloning artifact |
Ala 3 | - | cloning artifact |
PDB | External Database | Details |
---|---|---|
His -4 | - | cloning artifact |
Ser -3 | - | cloning artifact |
Arg -2 | - | cloning artifact |
Gly -1 | - | cloning artifact |
Gly 0 | Met 1 | conflict |
Gly 11 | - | linker |
Thr 12 | - | linker |
Gly 13 | - | linker |
Ser 14 | - | linker |
Gly 15 | - | linker |
Ser 16 | - | linker |
Gly 17 | - | linker |
Ser 18 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 46283.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 46947.0 |