1K2D
Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | H-2 class II histocompatibility antigen, A-U alpha chain | polymer | 189 | 21468.8 | 1 | UniProt (P14438) Pfam (PF00993) Pfam (PF07654) | Mus musculus (house mouse) | MHC CLASS II I-AU |
| 2 | B (B) | H-2 class II histocompatibility antigen, A-U beta chain | polymer | 189 | 22495.2 | 1 | UniProt (P06344) Pfam (PF00969) Pfam (PF07654) | Mus musculus (house mouse) | MHC CLASS II I-AU |
| 3 | C (P) | Myelin Basic Protein peptide with 8 residue linker peptide | polymer | 23 | 2319.4 | 1 | GenBank (14763906) UniProt (by SIFTS) (P02686) | MBP peptide | |
| 4 | D, E, F (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 5 | G, H, I (A, B, P) | water | water | 18.0 | 450 | Chemie (HOH) |
Sequence modifications
A: 4 - 181 (UniProt: P14438)
P: 0 - 10 (GenBank: 14763906)
| PDB | External Database | Details |
|---|---|---|
| His -6 | - | cloning artifact |
| Ser -5 | - | cloning artifact |
| Arg -4 | - | cloning artifact |
| Gly -3 | - | cloning artifact |
| Glu -2 | - | cloning artifact |
| Asp -1 | - | cloning artifact |
| Asp 0 | - | cloning artifact |
| Ile 1 | - | cloning artifact |
| Glu 2 | - | cloning artifact |
| Ala 3 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| His -4 | - | cloning artifact |
| Ser -3 | - | cloning artifact |
| Arg -2 | - | cloning artifact |
| Gly -1 | - | cloning artifact |
| Gly 0 | Met 1 | conflict |
| Gly 11 | - | linker |
| Thr 12 | - | linker |
| Gly 13 | - | linker |
| Ser 14 | - | linker |
| Gly 15 | - | linker |
| Ser 16 | - | linker |
| Gly 17 | - | linker |
| Ser 18 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 46283.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 46947.0 |
