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9AUC
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BU of 9auc by Molmil
Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
Deposit date:2024-02-28
Release date:2024-04-24
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
9BKK
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BU of 9bkk by Molmil
Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex
Descriptor: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
9BKJ
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BU of 9bkj by Molmil
Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
Descriptor: AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
8FX5
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BU of 8fx5 by Molmil
Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
Descriptor: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
Deposit date:2023-01-23
Release date:2023-09-13
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.45 Å)
Cite:Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Nat Commun, 14, 2023
7RTB
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BU of 7rtb by Molmil
Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Johnson, R.M, Danev, R, Sexton, P.M, Wootten, D.
Deposit date:2021-08-12
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (2.14 Å)
Cite:Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.
Biochem.Biophys.Res.Commun., 578, 2021
6NIY
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BU of 6niy by Molmil
A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Descriptor: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M.
Deposit date:2019-01-02
Release date:2019-01-23
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:The Molecular Control of Calcitonin Receptor Signaling.
Acs Pharmacol Transl Sci, 2, 2019
6B3J
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BU of 6b3j by Molmil
3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex
Descriptor: Exendin-P5, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liang, Y.L, Khoshouei, M, Glukhova, A, Furness, S.G.B, Koole, C, Zhao, P, Clydesdale, L, Thal, D.M, Radjainia, M, Danev, R, Baumeister, W, Wang, M.W, Miller, L.J, Christopoulos, A, Sexton, P.M, Wootten, D.
Deposit date:2017-09-22
Release date:2018-02-21
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature, 555, 2018
5DSG
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BU of 5dsg by Molmil
Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium
Descriptor: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ...
Authors:Thal, D.M, Kobilka, B.K, Sexton, P.M, Christopoulos, A.
Deposit date:2015-09-17
Release date:2016-03-16
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Nature, 531, 2016
5UEN
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BU of 5uen by Molmil
Crystal structure of the human adenosine A1 receptor A1AR-bRIL in complex with the covalent antagonist DU172 at 3.2A resolution
Descriptor: 4-{[3-(8-cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-3H-purin-3-yl)propyl]carbamoyl}benzene-1-sulfonyl fluoride, Adenosine receptor A1,Soluble cytochrome b562,Adenosine receptor A1, OLEIC ACID
Authors:Glukhova, A, Thal, D.M, Nguyen, A.T, Vecchio, E.A, Jorg, M, Scammells, P.J, May, L.T, Sexton, P.M, Christopoulos, A.
Deposit date:2017-01-03
Release date:2017-03-01
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity.
Cell, 168, 2017
5UZ7
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BU of 5uz7 by Molmil
Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Descriptor: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M.
Deposit date:2017-02-24
Release date:2017-05-03
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017
7MBY
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BU of 7mby by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
7MBX
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BU of 7mbx by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gs complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (1.95 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
4MQT
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BU of 4mqt by Molmil
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
Descriptor: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, ...
Authors:Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K.
Deposit date:2013-09-16
Release date:2013-11-27
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
4MQS
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BU of 4mqs by Molmil
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo
Descriptor: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, Nanobody 9-8
Authors:Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K.
Deposit date:2013-09-16
Release date:2013-11-27
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
9BUB
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BU of 9bub by Molmil
Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, Cagrilintide, Calcitonin receptor, ...
Authors:Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L.
Deposit date:2024-05-16
Release date:2025-04-23
Last modified:2025-04-30
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.
Nat Commun, 16, 2025
9BQ3
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BU of 9bq3 by Molmil
Human Amylin2 Receptor in Complex with Gs and Cagrilintide
Descriptor: Cagrilintide, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M, Johnson, R.M.
Deposit date:2024-05-08
Release date:2025-04-23
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Human Amylin2 Receptor in Complex with Gs and Cagrilintide
To Be Published
6PB1
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BU of 6pb1 by Molmil
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35
Descriptor: CHOLESTEROL, Corticotropin-releasing factor receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E.
Deposit date:2019-06-12
Release date:2020-02-12
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol.Cell, 77, 2020
9EBO
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BU of 9ebo by Molmil
Peptide 2 (GLP-1 (ACPC18)) bound to GLP-1R/Gs complex (conformer 1)
Descriptor: Glucagon-like peptide 1 receptor, Glucagon-like peptide 1(7-36), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cary, B.P, Hager, M.V, Mariam, Z, Morris, R.K, Belousoff, M.J, Deganutti, G, Wootten, D, Sexton, P.M, Gellman, S.H.
Deposit date:2024-11-12
Release date:2025-03-26
Last modified:2025-04-16
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Prolonged signaling of backbone-modified glucagon-like peptide- 1 analogues with diverse receptor trafficking.
Proc.Natl.Acad.Sci.USA, 122, 2025
9EBN
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BU of 9ebn by Molmil
Peptide 1 (GLP-1 (Aib16, ACPC18)) bound to GLP-1R/Gs complex
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cary, B.P, Hager, M.V, Mariam, Z, Morris, R.K, Belousoff, M.J, Deganutti, G, Wootten, D, Sexton, P.M, Gellman, S.H.
Deposit date:2024-11-12
Release date:2025-03-26
Last modified:2025-04-16
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Prolonged signaling of backbone-modified glucagon-like peptide- 1 analogues with diverse receptor trafficking.
Proc.Natl.Acad.Sci.USA, 122, 2025
9EBQ
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BU of 9ebq by Molmil
Peptide 2 (GLP-1 (ACPC18)) bound to GLP-1R/Gs complex (conformer 2)
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cary, B.P, Hager, M.V, Mariam, Z, Morris, R.K, Belousoff, M.J, Deganutti, G, Wootten, D, Sexton, P.M, Gellman, S.H.
Deposit date:2024-11-12
Release date:2025-03-26
Last modified:2025-04-16
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Prolonged signaling of backbone-modified glucagon-like peptide- 1 analogues with diverse receptor trafficking.
Proc.Natl.Acad.Sci.USA, 122, 2025
6PB0
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BU of 6pb0 by Molmil
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35
Descriptor: CHOLESTEROL, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E.
Deposit date:2019-06-12
Release date:2020-02-12
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol.Cell, 77, 2020
9BLC
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BU of 9blc by Molmil
Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation
Descriptor: Cagrilintide backbone (non-acylated), Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
Deposit date:2024-04-30
Release date:2025-04-16
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation
To Be Published
9BLB
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BU of 9blb by Molmil
Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in bypass conformation
Descriptor: Cagrilintide backbone (non-acylated), Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
Deposit date:2024-04-30
Release date:2025-04-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in bypass conformation
To Be Published
8FLS
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BU of 8fls by Molmil
Human PTH1R in complex with Abaloparatide and Gs
Descriptor: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLU
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BU of 8flu by Molmil
Human PTH1R in complex with LA-PTH and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023

 

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