5UEN

Crystal structure of the human adenosine A1 receptor A1AR-bRIL in complex with the covalent antagonist DU172 at 3.2A resolution

Summary for 5UEN

• Entry DOI: 10.2210/pdb5uen/pdb
• Descriptor: Adenosine receptor A1,Soluble cytochrome b562,Adenosine receptor A1, 4-{[3-(8-cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-3H-purin-3-yl)propyl]carbamoyl}benzene-1-sulfonyl fluoride, OLEIC ACID (3 entities in total)
• Functional Keywords: gpcr, transmembrane, receptor, adenosine, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 96136.47

Authors

Glukhova, A.,Thal, D.M.,Nguyen, A.T.,Vecchio, E.A.,Jorg, M.,Scammells, P.J.,May, L.T.,Sexton, P.M.,Christopoulos, A. (deposition date: 2017-01-03, release date: 2017-03-01, Last modification date: 2023-10-04)

• Primary citation: Glukhova, A.,Thal, D.M.,Nguyen, A.T.,Vecchio, E.A.,Jorg, M.,Scammells, P.J.,May, L.T.,Sexton, P.M.,Christopoulos, A.; Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity.; Cell, 168:867-877.e13, 2017; PubMed: 28235198; DOI: 10.1016/j.cell.2017.01.042

Experimental method

X-RAY DIFFRACTION (3.2 Å)