5DSG

Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium

Summary for 5DSG

• Entry DOI: 10.2210/pdb5dsg/pdb
• Descriptor: Muscarinic acetylcholine receptor M4,Endolysin,Endolysin,Muscarinic acetylcholine receptor M4, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, OLEIC ACID, ... (8 entities in total)
• Functional Keywords: membrane, gpcr, signaling, antagonist, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 100704.59

Authors

Thal, D.M.,Kobilka, B.K.,Sexton, P.M.,Christopoulos, A. (deposition date: 2015-09-17, release date: 2016-03-16, Last modification date: 2024-03-13)

• Primary citation: Thal, D.M.,Sun, B.,Feng, D.,Nawaratne, V.,Leach, K.,Felder, C.C.,Bures, M.G.,Evans, D.A.,Weis, W.I.,Bachhawat, P.,Kobilka, T.S.,Sexton, P.M.,Kobilka, B.K.,Christopoulos, A.; Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.; Nature, 531:335-340, 2016; PubMed: 26958838; DOI: 10.1038/nature17188

Experimental method

X-RAY DIFFRACTION (2.6 Å)