1MA3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ma3 by Molmil](/molmil-images/mine/1ma3) | Structure of a Sir2 enzyme bound to an acetylated p53 peptide | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cellular tumor antigen p53, Transcriptional regulatory protein, ... | Authors: | Avalos, J.L, Celic, I, Muhammad, S, Cosgrove, M.S, Boeke, J.D, Wolberger, C. | Deposit date: | 2002-07-31 | Release date: | 2002-10-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a Sir2 enzyme bound to an acetylated p53 peptide Mol.Cell, 10, 2002
|
|
1S7G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1s7g by Molmil](/molmil-images/mine/1s7g) | Structural Basis for the Mechanism and Regulation of Sir2 Enzymes | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5-DIPHOSPHORIBOSE, HEXAETHYLENE GLYCOL, ... | Authors: | Avalos, J.L, Boeke, J.D, Wolberger, C. | Deposit date: | 2004-01-29 | Release date: | 2004-03-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the mechanism and regulation of sir2 enzymes Mol.Cell, 13, 2004
|
|
1YC5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yc5 by Molmil](/molmil-images/mine/1yc5) | Sir2-p53 peptide-nicotinamide | Descriptor: | Cellular tumor antigen p53 peptide, NAD-dependent deacetylase, NICOTINAMIDE, ... | Authors: | Avalos, J.L, Bever, M.K, Wolberger, C. | Deposit date: | 2004-12-21 | Release date: | 2005-04-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol.Cell, 17, 2005
|
|
1YC2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yc2 by Molmil](/molmil-images/mine/1yc2) | Sir2Af2-NAD-ADPribose-nicotinamide | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent deacetylase 2, ... | Authors: | Avalos, J.L, Bever, M.K, Wolberger, C. | Deposit date: | 2004-12-21 | Release date: | 2005-03-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD(+) Cosubstrate Specificity of a Sir2 Enzyme. Mol.Cell, 17, 2005
|
|
2H4F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h4f by Molmil](/molmil-images/mine/2h4f) | Sir2-p53 peptide-NAD+ | Descriptor: | Cellular tumor antigen p53, NAD-dependent deacetylase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | Deposit date: | 2006-05-24 | Release date: | 2006-09-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
|
|
2H4H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h4h by Molmil](/molmil-images/mine/2h4h) | Sir2 H116Y mutant-p53 peptide-NAD | Descriptor: | Cellular tumor antigen p53, NAD-dependent deacetylase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | Deposit date: | 2006-05-24 | Release date: | 2006-09-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
|
|
2H59
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h59 by Molmil](/molmil-images/mine/2h59) | Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose | Descriptor: | (2S,3S,4R,5S)-2-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-4,5-DIHYDROXYTETRAHYDROFURAN-3-YL ACETATE, ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, ... | Authors: | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | Deposit date: | 2006-05-25 | Release date: | 2006-09-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
|
|
2H4J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h4j by Molmil](/molmil-images/mine/2h4j) | Sir2-deacetylated peptide (from enzymatic turnover in crystal) | Descriptor: | 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, NAD-dependent deacetylase, ... | Authors: | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | Deposit date: | 2006-05-24 | Release date: | 2006-09-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
|
|
3JYC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3jyc by Molmil](/molmil-images/mine/3jyc) | |
2H2I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h2i by Molmil](/molmil-images/mine/2h2i) | The Structural basis of Sirtuin Substrate Affinity | Descriptor: | (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL, NAD-dependent deacetylase, ZINC ION | Authors: | Cosgrove, M.S, Wolberger, C. | Deposit date: | 2006-05-18 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structural basis of sirtuin substrate affinity Biochemistry, 45, 2006
|
|
2H2H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h2h by Molmil](/molmil-images/mine/2h2h) | |
2H2G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h2g by Molmil](/molmil-images/mine/2h2g) | |
2H2D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h2d by Molmil](/molmil-images/mine/2h2d) | |
2H2F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h2f by Molmil](/molmil-images/mine/2h2f) | |